Substance / Medication

Repaglinide

Overview

Active Ingredient
repaglinide
RxNorm CUI
73044

Indications

Limitation of Use: Repaglinide tablets are indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.Repaglinide tablets should not be used in patients with type 1 diabetes mellitus or for the treatment of diabetic ketoacidosis.

Labeler: Bryant Ranch PrepackUpdated: 2025-11-04T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

Repaglinide tablets are contraindicated in patients with: Drug Interactions (7) [see] Concomitant use of gemfibrozil Known hypersensitivity to repaglinide or any inactive ingredients

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Clinical Trials

903 trials linked to this intervention

903
Total Trials
103
Recruiting
282
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Effects of CYP2C8 and SLCO1B1 Genetic Polymorphisms on Repaglinide Pharmacokinetics: A Systematic Review and Meta-Analysis.
Zhou Shuang, Xiang Qian, Mu Guangyan et al. · Curr Drug Metab · 2019
PMID: 30636597Meta-Analysis
Comparison of repaglinide and metformin versus metformin alone for type 2 diabetes: a meta-analysis of randomized controlled trials.
Yin Jinjin, Deng Houliang, Qin Shumin et al. · Diabetes Res Clin Pract · 2014
PMID: 25005849Meta-Analysis
Candesartan Has No Clinically Meaningful Effect on the Plasma Concentrations of Cytochrome P450 2C8 Substrate Repaglinide in Humans.
Piha Mikael O W, Cajanus Kristiina, Engström Marica T et al. · Drug Metab Dispos · 2024
PMID: 39486868RCT
A time to revisit the two oldest prandial anti-diabetes agents: acarbose and repaglinide.
Pishdad Parisa, Pishdad Reza, Pishdad Gholam Reza et al. · Endocrine · 2020
PMID: 32621047RCT
Bioequivalence of a fixed-dose repaglinide/metformin combination tablet and equivalent doses of repaglinide and metformin tablets
.
Cho Hea-Young, Ngo Lien, Kim Sang-Ki et al. · Int J Clin Pharmacol Ther · 2018
PMID: 29648532RCT

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Health Goals

Goals connected through associated conditions

Quick Facts

Type
Substance / Medication
Fully Specified Name
Repaglinide (substance)
SNOMED CT
386964000
UMLS CUI
C0246689
RxNorm CUI
73044
Labeler
Bryant Ranch Prepack

Clinical Data

This intervention maps to 10 entities in the Healos knowledge graph.

1
Conditions
4
Biomarkers
3
Specialists
0
Symptoms
903
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.