Substance / Medication

Selumetinib

Overview

Active Ingredient
selumetinib
RxNorm CUI
2289380

Indications

Dosage and Administration (2) [see]. KOSELUGO is indicated for the treatment of adult and pediatric patients 1 year of age and older with neurofibromatosis type 1 (NF1) who have symptomatic, inoperable plexiform neurofibromas (PN)

Labeler: AstraZeneca Pharmaceuticals LPUpdated: 2025-11-19T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

None.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Research Evidence

Published studies and systematic reviews

Sort:
Efficacy and Safety of Selumetinib in Pediatric Patients With Neurofibromatosis Type 1: A Systematic Review and Meta-analysis.
Hwang Jisun, Yoon Hee Mang, Lee Beom Hee et al. · Neurology · 2022
PMID: 35017312Meta-Analysis
Efficacy and safety of selumetinib compared with current therapies for advanced cancer: a meta-analysis.
Shen Chen-Tian, Qiu Zhong-Ling, Luo Quan-Yong · Asian Pac J Cancer Prev · 2014
PMID: 24716986Meta-Analysis
Effect of food on capsule and granule formulations of selumetinib.
Cohen-Rabbie Sarit, Mattinson Alexandra, So Karen et al. · Clin Transl Sci · 2022
PMID: 35170228RCTFull text (PMC)
Real-world experience with selumetinib in children with neurofibromatosis type 1: a multicentric retrospective study.
Santoro Claudia, Servedio Mariachiara, Diana Maria Cristina et al. · J Neurooncol · 2025
PMID: 40802118ObservationalFull text (PMC)
FDA Approval Summary: Selumetinib for Plexiform Neurofibroma.
Casey Denise, Demko Suzanne, Sinha Arup et al. · Clin Cancer Res · 2021
PMID: 33712511Observational

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Selumetinib (substance)
SNOMED CT
870689004
UMLS CUI
C2980074
RxNorm CUI
2289380
Labeler
AstraZeneca Pharmaceuticals LP

Clinical Data

This intervention maps to 1 entities in the Ltrl knowledge graph.

1
Conditions
0
Biomarkers
0
Specialists
0
Symptoms

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.