Substance / Medication

Simeprevir

Overview

Active Ingredient
simeprevir
RxNorm CUI
1482790

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

102 trials linked to this intervention

102
Total Trials
2
Recruiting
47
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Efficacy and safety of simeprevir for chronic hepatitis virus C genotype 1 infection: A meta-analysis.
Qu Yundong, Li Tao, Wang Lei et al. · Clin Res Hepatol Gastroenterol · 2016
PMID: 26216029Meta-Analysis
Sofosbuvir plus simeprevir for the treatment of genotype 1 chronic hepatitis C: a review of evidence.
Gimeno-Ballester Vicente, Simón Miguel Ángel, Trigo Cristina et al. · Expert Rev Gastroenterol Hepatol · 2016
PMID: 27626505Meta-Analysis
Patients eligible for treatment with simeprevir in a French center.
Morel Virginie, Duverlie Gilles, Brochot Etienne · J Clin Virol · 2014
PMID: 25027573Meta-Analysis
Evaluation of the Pharmacokinetics and Renal Excretion of Simeprevir in Subjects with Renal Impairment.
Ouwerkerk-Mahadevan Sivi, Beumont-Mauviel Maria, Mortier Steven et al. · Drugs R D · 2015
PMID: 26248593RCTFull text (PMC)
Outcomes of Treatment and Predictors of Response to Sofosbuvir Plus Simeprevir in Hepatitis C Virus with Genotype-4 Infection.
Ahmed Ossama A, Elsebaey Mohamed A, Fouad Mohamed Hassan A et al. · Infect Disord Drug Targets · 2020
PMID: 30569878Observational

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Simeprevir (substance)
SNOMED CT
708823009
UMLS CUI
C2605855
RxNorm CUI
1482790

Clinical Data

This intervention maps to 2 entities in the Healos knowledge graph.

2
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
102
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.