Substance / Medication

Sumatriptan

Overview

Active Ingredient
sumatriptan
RxNorm CUI
37418

Indications

Sumatriptan Nasal Spray is indicated for the acute treatment of migraine with or without aura in adults. Limitations of Use: • Use only if a clear diagnosis of migraine headache has been established. If a patient has no response to the first migraine attack treated with Sumatriptan Nasal Spray, reconsider the diagnosis of migraine before Sumatriptan Nasal Spray is administered to treat any subsequent attacks. • Sumatriptan is not indicated for the prevention of migraine attacks. • Safety and eff

Labeler: Prasco LaboratoriesUpdated: 2026-01-29T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

Sumatriptan Nasal Spray is contraindicated in patients with: • 5.1 [see Warnings and Precautions ()] Ischemic coronary artery disease (CAD) (angina pectoris, history of myocardial infarction, or documented silent ischemia) or coronary artery vasospasm, including Prinzmetal’s angina • 5.2 [see Warnin

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Research Evidence

Published studies and systematic reviews

Sort:
Beyond its anti-migraine properties, sumatriptan is an anti-inflammatory agent: A systematic review.
Ala Moein, Ghasemi Mehdi, Mohammad Jafari Razieh et al. · Drug Dev Res · 2021
PMID: 33792938Meta-Analysis
Intranasal sumatriptan for acute migraine attacks: a systematic review and meta-analysis.
Menshawy Amr, Ahmed Hussien, Ismail Ammar et al. · Neurol Sci · 2018
PMID: 28942578Meta-Analysis
Sumatriptan plus naproxen for the treatment of acute migraine attacks in adults.
Law Simon, Derry Sheena, Moore R Andrew · Cochrane Database Syst Rev · 2016
PMID: 27096438Meta-AnalysisFull text (PMC)
Sumatriptan (all routes of administration) for acute migraine attacks in adults - overview of Cochrane reviews.
Derry Christopher J, Derry Sheena, Moore R Andrew · Cochrane Database Syst Rev · 2014
PMID: 24865446Meta-AnalysisFull text (PMC)
Sumatriptan plus naproxen for acute migraine attacks in adults.
Law Simon, Derry Sheena, Moore R Andrew · Cochrane Database Syst Rev · 2013
PMID: 24142431Meta-Analysis
WITHDRAWN: Oral sumatriptan for acute migraine.
McCrory Douglas C, Gray Rebecca N · Cochrane Database Syst Rev · 2012
PMID: 22336784Meta-AnalysisFull text (PMC)
Sumatriptan (oral route of administration) for acute migraine attacks in adults.
Derry Christopher J, Derry Sheena, Moore R Andrew · Cochrane Database Syst Rev · 2012
PMID: 22336849Meta-AnalysisFull text (PMC)
Sumatriptan (intranasal route of administration) for acute migraine attacks in adults.
Derry Christopher J, Derry Sheena, Moore R Andrew · Cochrane Database Syst Rev · 2012
PMID: 22336867Meta-AnalysisFull text (PMC)
Sumatriptan (rectal route of administration) for acute migraine attacks in adults.
Derry Christopher J, Derry Sheena, Moore R Andrew · Cochrane Database Syst Rev · 2012
PMID: 22336868Meta-AnalysisFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Sumatriptan (substance)
SNOMED CT
395892000
UMLS CUI
C0075632
RxNorm CUI
37418
Labeler
Prasco Laboratories

Clinical Data

This intervention maps to 3 entities in the Healos knowledge graph.

3
Conditions
0
Biomarkers
0
Specialists
0
Symptoms

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.