Substance / Medication

Tagraxofusp

Overview

Active Ingredient
tagraxofusp
RxNorm CUI
2109055

Indications

ELZONRIS is indicated for the treatment of blastic plasmacytoid dendritic cell neoplasm (BPDCN) in adults and in pediatric patients 2 years and older.

Labeler: Stemline Therapeutics, Inc.Updated: 2024-12-09T00:00:00.000ZFull label on DailyMed

Boxed Warning

FDA Black Box Warning

5.1 [see Warnings and Precautions ()] Capillary Leak Syndrome (CLS) which may be life-threatening or fatal, can occur in patients receiving ELZONRIS. Monitor for signs and symptoms of CLS and take actions as recommended.

Contraindications

When this intervention should not be used

None.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Research Evidence

Published studies and systematic reviews

Sort:
Tagraxofusp for Blastic Plasmacytoid Dendritic Cell Neoplasm.
Hammond Danielle, Pemmaraju Naveen · Hematol Oncol Clin North Am · 2020
PMID: 32336420Meta-Analysis
Hematopoietic effects of tagraxofusp in treatment-naive patients with blastic plasmacytoid dendritic cell neoplasm.
Konopleva Marina, Pemmaraju Naveen, Sweet Kendra L et al. · Cancer · 2026
PMID: 41486505TrialFull text (PMC)
Tagraxofusp, a CD123-targeted therapy, for chronic myelomonocytic leukemia: final results of a phase 1/2 study.
Patnaik Mrinal M, Ali Haris, Wang Eunice S et al. · Blood Neoplasia · 2025
PMID: 40919483TrialFull text (PMC)
Final safety and efficacy results from a phase 1/2 study of tagraxofusp, a CD123-targeted therapy, for myelofibrosis.
Yacoub Abdulraheem, Ali Haris, Gupta Vikas et al. · Blood Neoplasia · 2025
PMID: 41146971TrialFull text (PMC)
Phase 1b trial of tagraxofusp in combination with azacitidine with or without venetoclax in acute myeloid leukemia.
Lane Andrew A, Garcia Jacqueline S, Raulston Evangeline G et al. · Blood Adv · 2024
PMID: 38052038TrialFull text (PMC)
Approval of tagraxofusp-erzs for blastic plasmacytoid dendritic cell neoplasm.
Pemmaraju Naveen, Konopleva Marina · Blood Adv · 2020
PMID: 32841341TrialFull text (PMC)
Tagraxofusp in Blastic Plasmacytoid Dendritic-Cell Neoplasm.
Pemmaraju Naveen, Lane Andrew A, Sweet Kendra L et al. · N Engl J Med · 2019
PMID: 31018069Trial

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Tagraxofusp (substance)
SNOMED CT
783435000
UMLS CUI
C4746084
RxNorm CUI
2109055
Labeler
Stemline Therapeutics, Inc.

Clinical Data

This intervention maps to 1 entities in the Ltrl knowledge graph.

1
Conditions
0
Biomarkers
0
Specialists
0
Symptoms

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.