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Substance / Medication

Timolol maleate

SNOMED 75359005UMLS C0087093

Overview

Clinical overview including description, indications, and evidence base is pending physician authorship or FDA SPL integration. Graph-derived relationship data is available below.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Myocardial infarction
High blood pressure
Pigmentary glaucoma
Heart failure
Open-angle glaucoma
Angina

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Cholesterol

LOINC 2093-3

secondary

Creatinine

LOINC 2160-0

secondary

Potassium

LOINC 2823-3

secondary

Creatine kinase isoenzymes

LOINC 13969-1

primary

Natriuretic peptide.B

LOINC 30934-4

primary

Natriuretic peptide.B prohormone N-Terminal

LOINC 33762-6

primary

Troponin T.cardiac

LOINC 6598-7

primary

Research Evidence

Published studies and systematic reviews

Sort:
Efficacy and safety of combined fractional carbon dioxide laser and topical timolol maleate 0.5% solution versus topical timolol maleate 0.5% solution alone in inflammatory facial acne; a randomized split face controlled study.
Gad El-Karim Mohamed Adel, Hegazy Mohammed Saad, Maged Asser et al. · Lasers Med Sci · 2025
PMID: 39891790RCT
Comparing the effects and safety of dorzolamide hydrochloride + timolol maleate versus brimonidine after neodymium-doped yttrium aluminium garnet laser capsulotomy posterior capsule opacification.
Çakmak Kaan, Erbil Hasan, Mesci Cem et al. · Eur J Ophthalmol · 2022
PMID: 34791912RCT
A randomized, controlled, split-face study of topical timolol maleate 0.5% eye drops for the treatment of erythematotelangiectatic rosacea.
Wei Danfeng, Hamblin Michael R, Wen Xiang · J Cosmet Dermatol · 2021
PMID: 34333845RCT
Topical 0.5% Timolol Maleate Significantly Enhances Skin-Barrier Restoration After Fractional Carbon Dioxide Laser Treatment for Acne Scars.
Kimwattananukul Kometh, Noppakun Nopadon, Asawanonda Pravit et al. · Lasers Surg Med · 2021
PMID: 33211352RCT
Short-term Efficacy and Safety of Topical β-Blockers (Timolol Maleate Ophthalmic Solution, 0.5%) in Acute Migraine: A Randomized Crossover Trial.
Kurian Abraham, Reghunadhan Iodine, Thilak Pratibha et al. · JAMA Ophthalmol · 2020
PMID: 33001159RCTFull text (PMC)
Randomised controlled trial: Can topical timolol maleate prevent complications for small superficial infantile haemangiomata in high-risk areas?
Cheng James W C H, Lam Ying-Yin, Fung Genevieve P G et al. · Pediatr Res · 2020
PMID: 32357362RCT
The efficacy and safety of bimatoprost/timolol maleate, latanoprost/timolol maleate, and travoprost/timolol maleate fixed combinations on 24-h IOP.
Guven Yilmaz Suzan, Degirmenci Cumali, Karakoyun Yunus Emre et al. · Int Ophthalmol · 2018
PMID: 28616797RCT
Evaluation of the effects on choroidal thickness of bimatoprost 0.03% versus a brinzolamide 1.0%/timolol maleate 0.5% fixed combination.
Akyol Nurettin, Kalkisim Ahmet, Turk Adem et al. · Cutan Ocul Toxicol · 2017
PMID: 28376651RCT
Effect of timolol maleate gel-forming solution on intraocular pressure, pupil diameter, and heart rate in normal and glaucomatous cats.
Kiland Julie A, Voss Andrea M, McLellan Gillian J · Vet Ophthalmol · 2016
PMID: 26991029RCTFull text (PMC)
Effects of perioperative topical dorzolamide hydrochloride-timolol maleate administration on incidence and severity of postoperative ocular hypertension in dogs undergoing cataract extraction by phacoemulsification.
Matusow Rachel B, Herring Ian P, Pickett J Phillip et al. · J Am Vet Med Assoc · 2016
PMID: 27767427RCT

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Specialists

Providers who commonly manage this intervention

Internal Medicine Physician

Internal Medicine

NUCC 207R00000X
Cardiovascular Disease Physician

Internal Medicine — Cardiovascular Disease

NUCC 207RC0000X
Interventional Cardiology Physician

Internal Medicine — Interventional Cardiology

NUCC 207RI0011X
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Health Goals

Goals connected through associated conditions

Improve Cardiovascular Fitness

Quick Facts

Type
Substance / Medication
Fully Specified Name
Timolol maleate (substance)
SNOMED CT
75359005
UMLS CUI
C0087093

Clinical Data

This intervention maps to 17 entities in the Healos knowledge graph.

6
Conditions
7
Biomarkers
3
Specialists
0
Symptoms

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.