Substance / Medication

Topiramate

Overview

Active Ingredient
topiramate
RxNorm CUI
38404
Labeler: Advanced Rx of Tennessee, LLCUpdated: 2026-02-18T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

None.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Clinical Trials

39 trials linked to this intervention

39
Total Trials
6
Recruiting
19
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Effectiveness of Topiramate Versus Acetazolamide in the Management of Idiopathic Intracranial Hypertension: ASystematic Review and Meta-Analysis.
Almaqhawi Abdullah, Alokley Alia, Alamri Reham et al. · Medicina (Kaunas) · 2025
PMID: 40142261Meta-AnalysisFull text (PMC)
Efficacy of topiramate in reducing second-generation antipsychotic-associated weight gain among children: A systematic review and meta-analysis.
Costa Gabriel P A, Moraes Vitor R Y, Assunção Beatriz R et al. · Diabetes Obes Metab · 2024
PMID: 38477159Meta-Analysis
European Headache Federation (EHF) critical reappraisal and meta-analysis of oral drugs in migraine prevention - part 3: topiramate.
Raffaelli Bianca, García-Azorín David, Boucherie Deirdre M et al. · J Headache Pain · 2023
PMID: 37814223Meta-AnalysisFull text (PMC)
A Bayesian meta-analysis of topiramate's effectiveness for individuals with alcohol use disorder.
Fluyau Dimy, Kailasam Vasanth Kattalai, Pierre Christopher G · J Psychopharmacol · 2023
PMID: 36648091Meta-Analysis
Efficacy and safety of topiramate for reducing impulsivity: A transdiagnostic systematic review and meta-analysis of a common clinical use.
Chapron Sophie-Athéna, Nourredine Mikail, Dondé Clément et al. · Fundam Clin Pharmacol · 2022
PMID: 34212434Meta-Analysis
Use of Topiramate in the Spectrum of Addictive and Eating Disorders: A Systematic Review Comparing Treatment Schemes, Efficacy, and Safety Features.
Nourredine Mikail, Jurek Lucie, Angerville Bernard et al. · CNS Drugs · 2021
PMID: 33591567Meta-Analysis
Behavioral adverse events with brivaracetam, levetiracetam, perampanel, and topiramate: A systematic review.
Steinhoff Bernhard J, Klein Pavel, Klitgaard Henrik et al. · Epilepsy Behav · 2021
PMID: 33839453Meta-Analysis
Efficacy of topiramate as an add-on therapy in patients with refractory status epilepticus: a short systematic review.
Welling Leonardo Christiaan, Rabelo Nícollas Nunes, Yoshikawa Marcia Harumy et al. · Rev Bras Ter Intensiva · 2021
PMID: 35107556Meta-AnalysisFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Specialists

Providers who commonly manage this intervention

Health Goals

Goals connected through associated conditions

Quick Facts

Type
Substance / Medication
Fully Specified Name
Topiramate (substance)
SNOMED CT
386844006
UMLS CUI
C0076829
RxNorm CUI
38404
Labeler
Advanced Rx of Tennessee, LLC

Clinical Data

This intervention maps to 10 entities in the Healos knowledge graph.

5
Conditions
3
Biomarkers
1
Specialists
0
Symptoms
39
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.