Substance / Medication

Triazolam

Overview

Active Ingredient
triazolam
RxNorm CUI
10767

Indications

Triazolam is indicated for the short-term treatment of insomnia (generally 7 to 10 days) in adults.

Labeler: Mylan Pharmaceuticals Inc.Updated: 2026-01-29T00:00:00.000ZFull label on DailyMed

Boxed Warning

FDA Black Box Warning

• Warnings and Precautions (5.1) Drug Interactions (7.1) [see,] Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death. Reserve concomitant prescribing of these drugs in patients for whom alternative treatment options are inadequate. L

Contraindications

When this intervention should not be used

Triazolam is contraindicated in: • Patients with known hypersensitivity to triazolam, any of component of triazolam, or other benzodiazepines. Reactions consistent with angioedema (involving the tongue, glottis, or larynx), dyspnea, and throat closing have been reported and may be fatal. • Warnings

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

2 trials linked to this intervention

2
Total Trials
1
Recruiting
1
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Effects of different doses of triazolam in the middle-of-the-night insomnia: a double-blind, randomized, parallel group study.
Ferini Strambi Luigi, Marelli Sara, Zucconi Marco et al. · J Neurol · 2017
PMID: 28584913RCT
Residual effects of zolpidem, triazolam, rilmazafone and placebo in healthy elderly subjects: a randomized double-blind study.
Uemura Sachiko Ito, Kanbayashi Takashi, Wakasa Masahiko et al. · Sleep Med · 2015
PMID: 26498242RCT
Effects of dosing interval on the pharmacokinetic and pharmacodynamic interactions between the oral adsorbent AST-120 and triazolam in humans.
Kotegawa Tsutomu, Tsutsumi Kimiko, Morita Hajime et al. · Eur J Clin Pharmacol · 2012
PMID: 22644342RCT
Physiological doses of progesterone potentiate the effects of triazolam in healthy, premenopausal women.
Babalonis Shanna, Lile Joshua A, Martin Catherine A et al. · Psychopharmacology (Berl) · 2011
PMID: 21350928RCTFull text (PMC)
Progesterone effects on the discriminative stimulus, subjective and performance effects of triazolam in healthy, premenopausal women.
Babalonis Shanna, Lile Joshua A, Martin Catherine A et al. · Behav Pharmacol · 2011
PMID: 21808190RCTFull text (PMC)
Modulation of the discriminative stimulus effects of triazolam across the menstrual cycle phase in healthy pre-menopausal women.
Babalonis Shanna, Emurian Cleeve S, Martin Catherine A et al. · Drug Alcohol Depend · 2008
PMID: 18178039RCTFull text (PMC)
Relative abuse liability of indiplon and triazolam in humans: a comparison of psychomotor, subjective, and cognitive effects.
Carter Lawrence P, Griffiths Roland R, Suess Patricia E et al. · J Pharmacol Exp Ther · 2007
PMID: 17502431RCT
Dose effects of triazolam on brain activity during episodic memory encoding: a PET study.
Mintzer Miriam Z, Kuwabara Hiroto, Alexander Mohab et al. · Psychopharmacology (Berl) · 2006
PMID: 16847681RCT
Decreasing pain and anxiety associated with patient-activated atrial shock: a placebo-controlled study of adjunctive sedation with oral triazolam.
Fabian Tanya J, Schwartzman David S, Ujhelyi Michael R et al. · J Cardiovasc Electrophysiol · 2006
PMID: 16643361RCT

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Triazolam (substance)
SNOMED CT
386984001
UMLS CUI
C0040879
RxNorm CUI
10767
Labeler
Mylan Pharmaceuticals Inc.

Clinical Data

This intervention maps to 1 entities in the Ltrl knowledge graph.

1
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
2
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.