Substance / Medication

Urea

Overview

Active Ingredient
urea
RxNorm CUI
11002

Indications

For debridement and promotion of normal healing of hyperkeratotic surface lesions, particularly where healing is retarded by local infection, necrotic tissue, fibrinous or purulent debris or eschar. Urea is useful for the treatment of hyperkeratotic conditions such as dry, rough skin, dermatitis, psoriasis, xerosis, ichthyosis, eczema, keratosis pilaris, keratosis palmaris, keratoderma, corns and calluses, as well as damaged, ingrown and devitalized nails. Soothes rough and dry skin.

Labeler: PureTek CorporationUpdated: 2026-02-20T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

This product is contraindicated in persons with known or suspected hypersensitivity to any of the ingredients of the product.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Research Evidence

Published studies and systematic reviews

Sort:
Impact of telehealth on hydroxyurea adherence and clinical outcomes in sickle cell disease management: A systematic review and meta-analysis.
Akosah Akwasi, Gokhale Pooja, Villa Zapata Lorenzo · J Manag Care Spec Pharm · 2026
PMID: 41439376Meta-AnalysisFull text (PMC)
Safety of Hydroxyurea in Pregnancy: A Systematic Review of the Literature.
Al Sulaimani Ruqaiya, Zitoun Natalie, Alothman Hessah et al. · J Obstet Gynaecol Can · 2025
PMID: 40381805Meta-Analysis
Sulfonylurea drugs for people with severe hemispheric ischemic stroke.
Fan Linlin, Xu Jin, Wang Tao et al. · Cochrane Database Syst Rev · 2025
PMID: 40066941Meta-AnalysisFull text (PMC)
Urea to Treat Hyponatremia Due to Syndrome of Inappropriate Antidiuretic Hormone Secretion: A Systematic Review and Meta-Analysis.
Chander Subhash, Kumari Roopa, Lohana Abhi Chand et al. · Am J Kidney Dis · 2025
PMID: 39362395Meta-Analysis
The urea-to-creatinine ratio as an emerging biomarker in critical care: a scoping review and meta-analysis.
Paulus Michelle Carmen, Melchers Max, van Es Anouck et al. · Crit Care · 2025
PMID: 40317012Meta-AnalysisFull text (PMC)
Global prevalence, resistance rates, and underlying resistance mechanisms of clinical Mycoplasma and Ureaplasma species.
Ramaloko Winnie Thabisa, Maningi Nontuthuko Excellent, Osei Sekyere John · J Appl Microbiol · 2025
PMID: 39719365Meta-Analysis
A systematic review and meta-analysis of cow-level factors affecting milk urea nitrogen and urinary nitrogen output under pasture-based diets.
Mangwe Mancoba C, Mason Winston A, Reed Charlotte B et al. · J Dairy Sci · 2025
PMID: 39369898Meta-Analysis
Assessing milk urea nitrogen as an indicator of protein nutrition and nitrogen utilization efficiency: A meta-analysis.
Zhao Xiaowei, Zang Changjiang, Zhao Shengguo et al. · J Dairy Sci · 2025
PMID: 39947598Meta-Analysis

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Urea (substance)
SNOMED CT
387092000
UMLS CUI
C0041942
RxNorm CUI
11002
Labeler
PureTek Corporation

Clinical Data

This intervention maps to 2 entities in the Healos knowledge graph.

2
Conditions
0
Biomarkers
0
Specialists
0
Symptoms

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.