Substance / Medication

Urea

Overview

Active Ingredient
urea
RxNorm CUI
11002

Indications

For debridement and promotion of normal healing of hyperkeratotic surface lesions, particularly where healing is retarded by local infection, necrotic tissue, fibrinous or purulent debris or eschar. Urea is useful for the treatment of hyperkeratotic conditions such as dry, rough skin, dermatitis, psoriasis, xerosis, ichthyosis, eczema, keratosis pilaris, keratosis palmaris, keratoderma, corns and calluses, as well as damaged, ingrown and devitalized nails. Soothes rough and dry skin.

Labeler: PureTek CorporationUpdated: 2026-02-20T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

This product is contraindicated in persons with known or suspected hypersensitivity to any of the ingredients of the product.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Research Evidence

Published studies and systematic reviews

Sort:
Urea to Treat Hyponatremia Due to Syndrome of Inappropriate Antidiuretic Hormone Secretion: A Systematic Review and Meta-Analysis.
Chander Subhash, Kumari Roopa, Lohana Abhi Chand et al. · Am J Kidney Dis · 2025
PMID: 39362395Meta-Analysis
A systematic review and meta-analysis of cow-level factors affecting milk urea nitrogen and urinary nitrogen output under pasture-based diets.
Mangwe Mancoba C, Mason Winston A, Reed Charlotte B et al. · J Dairy Sci · 2025
PMID: 39369898Meta-Analysis
Assessing milk urea nitrogen as an indicator of protein nutrition and nitrogen utilization efficiency: A meta-analysis.
Zhao Xiaowei, Zang Changjiang, Zhao Shengguo et al. · J Dairy Sci · 2025
PMID: 39947598Meta-Analysis
The urea-to-creatinine ratio as an emerging biomarker in critical care: a scoping review and meta-analysis.
Paulus Michelle Carmen, Melchers Max, van Es Anouck et al. · Crit Care · 2025
PMID: 40317012Meta-AnalysisFull text (PMC)
Saliva urea nitrogen for detection of kidney disease in adults: A meta-analysis of diagnostic test accuracy.
Kumaran Reyna, Abdalla Mona Mohamed Ibrahim, Caszo Brinnell Annette et al. · PLoS One · 2025
PMID: 40440346Meta-AnalysisFull text (PMC)
Efficacy and Safety of 40% Urea as an Adjuvant to Antifungals for Onychomycosis: A Systematic Review and Meta-Analysis.
Kurniasari Fitra Tri, Ervianti Evy, Damayanti et al. · Mycoses · 2025
PMID: 40827600Meta-Analysis
Urea breath test forinfection in adult dyspeptic patients: A meta-analysis of diagnostic test accuracy.
Lemos Fabian Fellipe Bueno, de Castro Caroline Tianeze, Silva Luz Marcel et al. · World J Gastroenterol · 2024
PMID: 38463019Meta-AnalysisFull text (PMC)
Utility of fractional excretion of urea in acute kidney injury with comparison to fractional excretion of sodium: A systematic review and meta-analysis.
Abdelhafez Mohammad O, Alhroob Asil A, Abu Hawilla Mustafa O et al. · Am J Med Sci · 2024
PMID: 38768779Meta-Analysis
Blood urea nitrogen/creatinine ratio in heart failure: Systematic review and meta-analysis.
Zhou Yichang, Zhao Qin, Liu Zhitong et al. · PLoS One · 2024
PMID: 38805436Meta-AnalysisFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Urea (substance)
SNOMED CT
387092000
UMLS CUI
C0041942
RxNorm CUI
11002
Labeler
PureTek Corporation

Clinical Data

This intervention maps to 2 entities in the Ltrl knowledge graph.

2
Conditions
0
Biomarkers
0
Specialists
0
Symptoms

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.