Substance / Medication

Venetoclax

Overview

Active Ingredient
venetoclax
RxNorm CUI
1747556
Labeler: AbbVie Inc.Updated: 2024-07-12T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

strong [see Dosage and Administration ( 2.6 ) and Drug Interactions ( 7.1 )] Concomitant use of VENCLEXTA withCYP3A inhibitors at initiation and during the ramp-up phase is contraindicated in patients with CLL/SLL due to the potential for increased risk of tumor lysis syndrome.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

2 trials linked to this intervention

2
Total Trials
1
Recruiting
1
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Is Antifungal Prophylaxis Needed for Acute Myeloid Leukaemia Patients Treated With Venetoclax-Based Regimens? A Systematic Review and Meta-Analysis.
Passos Pedro Robson Costa, Filho Valbert Oliveira Costa, Noronha Mariana Macambira et al. · Mycoses · 2025
PMID: 40598802Meta-Analysis
Comparative efficacy of venetoclax and hypomethylating agents in acute myeloid leukemia treatment: a meta-analysis of clinical trials and Real-World outcomes.
Sanz-Solas Antonio, Saiz-Rodríguez Miriam, Simal Sara Calvo et al. · Ann Hematol · 2025
PMID: 40884567Meta-AnalysisFull text (PMC)
A systematic review of venetoclax for the treatment of unfit AML patients in real-world: is all that glitters gold?
Solana-Altabella Antonio, Rodríguez-Veiga Rebeca, Martínez-Cuadrón David et al. · Ann Hematol · 2025
PMID: 39150561Meta-AnalysisFull text (PMC)
Risk assessment of venetoclax-associated adverse events: a meta-analysis approach.
Wu Tung-Lung, Chen Chao-Kun, Chao Chien-Ming et al. · Expert Opin Drug Saf · 2025
PMID: 39829042Meta-Analysis
Evidence-based investigation of the efficacy and safety of venetoclax-containing regimens versus chemoimmunotherapy in chronic lymphocytic leukemia.
Yao Pu, Zhang Jiao, Wang Xiaowen et al. · Naunyn Schmiedebergs Arch Pharmacol · 2025
PMID: 39992421Meta-Analysis

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Venetoclax (substance)
SNOMED CT
720491001
UMLS CUI
C4079830
RxNorm CUI
1747556
Labeler
AbbVie Inc.

Clinical Data

This intervention maps to 1 entities in the Healos knowledge graph.

1
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
2
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.