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MARILYN GOWEN, M.D.
M.D.
Pediatric Pulmonology Physician
NPI: 1053361683Individual
Specialties, Licenses & Credentials
Pediatrics — Pediatric Pulmonology
Code: 2080P0214X
0101045398(VA)
Research & Publications (20)
Antagonizing the parathyroid calcium receptor stimulates parathyroid hormone secretion and bone formation in osteopenic rats.
PMID 10841518·J Clin Invest·2000
7-preclinical
Antagonists of the calcium receptor I. Amino alcohol-based parathyroid hormone secretagogues.
PMID 19492813·J Med Chem·2009
7-preclinical
Method for quantitative protein-ligand affinity measurements in compound mixtures.
PMID 17500537·Anal Chem·2007
8-other
A highly potent inhibitor of cathepsin K (relacatib) reduces biomarkers of bone resorption both in vitro and in an acute model of elevated bone turnover in vivo in monkeys.
PMID 16962401·Bone·2007
7-preclinical
An azepanone-based inhibitor of human cathepsin K with improved oral bioavailability in the rat and the monkey.
PMID 15832505·Mol Pharm·2004
7-preclinical
Rapid inhibition of thyroxine-induced bone resorption in the rat by an orally active vitronectin receptor antagonist.
PMID 12065718·J Pharmacol Exp Ther·2002
7-preclinical
A potent small molecule, nonpeptide inhibitor of cathepsin K (SB 331750) prevents bone matrix resorption in the ovariectomized rat.
PMID 11996914·Bone·2002
7-preclinical
Clusterin expression in adult human normal and osteoarthritic articular cartilage.
PMID 11795992·Osteoarthritis Cartilage·2001
8-other
Identification and initial characterization of 5000 expressed sequenced tags (ESTs) each from adult human normal and osteoarthritic cartilage cDNA libraries.
PMID 11597177·Osteoarthritis Cartilage·2001
8-other
Potent and selective inhibition of human cathepsin K leads to inhibition of bone resorption in vivo in a nonhuman primate.
PMID 11585335·J Bone Miner Res·2001
7-preclinical
Calcilytic compounds: potent and selective Ca2+ receptor antagonists that stimulate secretion of parathyroid hormone.
PMID 11561095·J Pharmacol Exp Ther·2001
7-preclinical
Antagonism of oestrogen action in human breast and endometrial cells in vitro: potential novel antitumour agents.
PMID 11391860·Cancer Chemother Pharmacol·2001
8-other
Changes in bone turnover following gonadotropin-releasing hormone (GnRH) agonist administration and estrogen treatment in cynomolgus monkeys: a short-term model for evaluation of antiresorptive therapy.
PMID 11344053·Bone·2001
7-preclinical
IL-1- and TNF-induced bone resorption is mediated by p38 mitogen activated protein kinase.
PMID 11319753·J Cell Physiol·2001
7-preclinical
Human osteoclast cathepsin K is processed intracellularly prior to attachment and bone resorption.
PMID 11277265·J Bone Miner Res·2001
8-other
Biosynthesis and processing of cathepsin K in cultured human osteoclasts.
PMID 11248658·Bone·2001
8-other
Data courtesy of the U.S. National Library of Medicine (NLM). Ltrl is not affiliated with or endorsed by NLM.
Contact & Hours
- Address
- 601 CHILDRENS LN
NORFOLK, VA 23507 - Phone
- (757) 668-7426
Quick Facts
- NPI
- 1053361683
- Entity Type
- Individual
- Gender
- Female
- Medicare
- Not confirmed
- Specialties
- 2
- Locations
- 1
- Publications
- 20
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