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ISAAC WILLIAM BROWDER MD
MD
Surgery Physician
NPI: 1124011481Individual
Specialties, Licenses & Credentials
Surgery PhysicianPrimary
Surgery
Code: 208600000X
MD20468(TN)
Research & Publications (18)
Preconditioning with a TLR2 specific ligand increases resistance to cerebral ischemia/reperfusion injury.
PMID 18585792·J Neuroimmunol·2008
7-preclinical
Protection against myocardial ischemia/reperfusion injury in TLR4-deficient mice is mediated through a phosphoinositide 3-kinase-dependent mechanism.
PMID 17513782·J Immunol·2007
7-preclinical
Activation of Toll-like receptor 4 signaling contributes to hippocampal neuronal death following global cerebral ischemia/reperfusion.
PMID 17884182·J Neuroimmunol·2007
7-preclinical
Blockade of MyD88 attenuates cardiac hypertrophy and decreases cardiac myocyte apoptosis in pressure overload-induced cardiac hypertrophy in vivo.
PMID 16199478·Am J Physiol Heart Circ Physiol·2006
7-preclinical
The development of a novel mouse model of transient global cerebral ischemia.
PMID 16513265·Neurosci Lett·2006
4-observational
Glucan phosphate attenuates cardiac dysfunction and inhibits cardiac MIF expression and apoptosis in septic mice.
PMID 16766637·Am J Physiol Heart Circ Physiol·2006
7-preclinical
Blocking the MyD88-dependent pathway protects the myocardium from ischemia/reperfusion injury in rat hearts.
PMID 16259957·Biochem Biophys Res Commun·2005
7-preclinical
Attenuation of cardiac hypertrophy by inhibiting both mTOR and NFkappaB activation in vivo.
PMID 16298682·Free Radic Biol Med·2005
4-observational
Overexpression of TLR2 and TLR4 susceptibility to serum deprivation-induced apoptosis in CHO cells.
PMID 16213463·Biochem Biophys Res Commun·2005
7-preclinical
NF-kappaB activation is required for the development of cardiac hypertrophy in vivo.
PMID 15142841·Am J Physiol Heart Circ Physiol·2004
7-preclinical
At low serum glucan concentrations there is an inverse correlation between serum glucan and serum cytokine levels in ICU patients with infections.
PMID 15222986·Int Immunopharmacol·2004
4-observational
Modulation of tissue Toll-like receptor 2 and 4 during the early phases of polymicrobial sepsis correlates with mortality.
PMID 12794424·Crit Care Med·2003
7-preclinical
Human vascular endothelial cells express pattern recognition receptors for fungal glucans which stimulates nuclear factor kappaB activation and interleukin 8 production. Winner of the Best Paper Award from the Gold Medal Forum.
PMID 12079131·Am Surg·2002
8-other
Human monocyte scavenger receptors are pattern recognition receptors for (1-->3)-beta-D-glucans.
PMID 12101273·J Leukoc Biol·2002
8-other
Normal human fibroblasts express pattern recognition receptors for fungal (1-->3)-beta-D-glucans.
PMID 11349061·Infect Immun·2001
8-other
Glucans exhibit weak antioxidant activity, but stimulate macrophage free radical activity.
PMID 11182295·Free Radic Biol Med·2001
7-preclinical
Early activation of IKKbeta during in vivo myocardial ischemia.
PMID 11179072·Am J Physiol Heart Circ Physiol·2001
7-preclinical
Data courtesy of the U.S. National Library of Medicine (NLM). Ltrl is not affiliated with or endorsed by NLM.
Contact & Hours
- Address
- 325 N STATE OF FRANKLIN RD, 3RD FLOOR
JOHNSON CITY, TN 37604 - Phone
- (423) 439-7201
Quick Facts
- NPI
- 1124011481
- Entity Type
- Individual
- Gender
- Male
- Medicare
- Not confirmed
- Specialties
- 1
- Locations
- 1
- Publications
- 18
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