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DAVID HARDEN, MD
MD
Dermatology Physician
NPI: 1134184245Individual
Specialties, Licenses & Credentials
Dermatology PhysicianPrimary
Dermatology
Code: 207N00000X
0425336(KS)
Research & Publications (13)
Preliminary SAR studies on non-apamin-displacing 4-(aminomethylaryl)pyrrazolopyrimidine K(Ca) channel blockers.
PMID 18824351·Bioorg Med Chem Lett·2008
8-other
Characterization of the 5-HT2b receptor in evaluation of aequorin detection of calcium mobilization for miniaturized GPCR high-throughput screening.
PMID 18566482·J Biomol Screen·2008
7-preclinical
Initial SAR studies on apamin-displacing 2-aminothiazole blockers of calcium-activated small conductance potassium channels.
PMID 18774291·Bioorg Med Chem Lett·2008
8-other
(S,E)-N-[1-(3-heteroarylphenyl)ethyl]-3-(2-fluorophenyl)acrylamides: synthesis and KCNQ2 potassium channel opener activity.
PMID 15603955·Bioorg Med Chem Lett·2005
7-preclinical
BL-1249 [(5,6,7,8-tetrahydro-naphthalen-1-yl)-[2-(1H-tetrazol-5-yl)-phenyl]-amine]: a putative potassium channel opener with bladder-relaxant properties.
PMID 15608074·J Pharmacol Exp Ther·2005
7-preclinical
Synthesis and KCNQ2 opener activity of N-(1-benzo[1,3]dioxol-5-yl-ethyl, N-[1-(2,3-dihydro-benzofuran-5-yl)-ethyl, and N-[1-(2,3-dihydro-1H-indol-5-yl)-ethyl acrylamides.
PMID 15357987·Bioorg Med Chem Lett·2004
7-preclinical
A thallium-sensitive, fluorescence-based assay for detecting and characterizing potassium channel modulators in mammalian cells.
PMID 15634793·J Biomol Screen·2004
8-other
(S)-N-[1-(4-cyclopropylmethyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-ethyl]-3-(2-fluoro-phenyl)-acrylamide is a potent and efficacious KCNQ2 opener which inhibits induced hyperexcitability of rat hippocampal neurons.
PMID 15050644·Bioorg Med Chem Lett·2004
7-preclinical
Lichen planus associated with hepatitis C virus: no viral transcripts are found in the lichen planus, and effective therapy for hepatitis C virus does not clear lichen planus.
PMID 14576663·J Am Acad Dermatol·2003
8-other
Fluorine substitution can block CYP3A4 metabolism-dependent inhibition: identification of (S)-N-[1-(4-fluoro-3- morpholin-4-ylphenyl)ethyl]-3- (4-fluorophenyl)acrylamide as an orally bioavailable KCNQ2 opener devoid of CYP3A4 metabolism-dependent inhibition.
PMID 12930139·J Med Chem·2003
7-preclinical
(S)-N-[1-(3-morpholin-4-ylphenyl)ethyl]- 3-phenylacrylamide: an orally bioavailable KCNQ2 opener with significant activity in a cortical spreading depression model of migraine.
PMID 12852750·J Med Chem·2003
7-preclinical
Teledermatology: an intraobserver diagnostic correlation study, Part II.
PMID 12839260·Cutis·2003
4-observational
Teledermatology: an intraobserver diagnostic correlation study, part I.
PMID 12769408·Cutis·2003
4-observational
Data courtesy of the U.S. National Library of Medicine (NLM). Ltrl is not affiliated with or endorsed by NLM.
Contact & Hours
- Address
- 2051 E MARY ST
GARDEN CITY, KS 67846 - Phone
- (620) 277-9092
Quick Facts
- NPI
- 1134184245
- Entity Type
- Individual
- Gender
- Male
- Medicare
- Not confirmed
- Specialties
- 1
- Locations
- 1
- Publications
- 13
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