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ANNAPURNA SAKSENA, M.D.
M.D.
Anatomic Pathology & Clinical Pathology Physician
NPI: 1154771160IndividualAccepts Medicare
Specialties, Licenses & Credentials
Anatomic Pathology & Clinical Pathology PhysicianPrimary
Pathology — Anatomic Pathology & Clinical Pathology
Code: 207ZP0102X
MD468031(PA)
Education
OTHER
Class of 2010
Research & Publications (20)
Toward the back-up of boceprevir (SCH 503034): discovery of new extended P4-capped ketoamide inhibitors of hepatitis C virus NS3 serine protease with improved potency and pharmacokinetic profiles.
PMID 19456105·J Med Chem·2009
7-preclinical
Toward second generation hepatitis C virus NS3 serine protease inhibitors: discovery of novel P4 modified analogues with improved potency and pharmacokinetic profile.
PMID 19371095·J Med Chem·2009
7-preclinical
Posaconazole (Noxafil, SCH 56592), a new azole antifungal drug, was a discovery based on the isolation and mass spectral characterization of a circulating metabolite of an earlier lead (SCH 51048).
PMID 18059003·J Mass Spectrom·2008
7-preclinical
Hepatitis C virus NS3-4A serine protease inhibitors: SAR of new P1 derivatives of SCH 503034.
PMID 18547808·Bioorg Med Chem Lett·2008
8-other
Key steps in the structure-based optimization of the hepatitis C virus NS3/4A protease inhibitor SCH503034.
PMID 18421139·J Synchrotron Radiat·2008
8-other
Characterization of resistance mutations against HCV ketoamide protease inhibitors.
PMID 18201776·Antiviral Res·2008
8-other
Discovery of the HCV NS3/4A protease inhibitor (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034) II. Key steps in structure-based optimization.
PMID 17444623·J Med Chem·2007
8-other
In vitro antiviral activity of SCH446211 (SCH6), a novel inhibitor of the hepatitis C virus NS3 serine protease.
PMID 17151003·J Antimicrob Chemother·2007
8-other
Hydroxylated analogues of the orally active broad spectrum antifungal, Sch 51048 (1), and the discovery of posaconazole [Sch 56592; 2 or (S,S)-5].
PMID 16260134·Bioorg Med Chem Lett·2006
7-preclinical
Mutations conferring resistance to SCH6, a novel hepatitis C virus NS3/4A protease inhibitor. Reduced RNA replication fitness and partial rescue by second-site mutations.
PMID 16352601·J Biol Chem·2006
8-other
Depeptidization efforts on P3-P2' alpha-ketoamide inhibitors of HCV NS3-4A serine protease: effect on HCV replicon activity.
PMID 16387495·Bioorg Med Chem Lett·2006
8-other
Discovery of SCH446211 (SCH6): a new ketoamide inhibitor of the HCV NS3 serine protease and HCV subgenomic RNA replication.
PMID 16640336·J Med Chem·2006
7-preclinical
Discovery of (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]- 3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (SCH 503034), a selective, potent, orally bioavailable hepatitis C virus NS3 protease inhibitor: a potential therapeutic agent for the treatment of hepatitis C infection.
PMID 17004721·J Med Chem·2006
7-preclinical
Hepatitis C virus NS3-4A serine protease inhibitors: use of a P2-P1 cyclopropyl alanine combination for improved potency.
PMID 16112862·Bioorg Med Chem Lett·2005
8-other
Hepatitis C virus NS3-4A serine protease inhibitors: SAR of P'2 moiety with improved potency.
PMID 16087332·Bioorg Med Chem Lett·2005
8-other
Novel inhibitors of the hepatitis C virus NS3 proteinase.
PMID 16087334·Bioorg Med Chem Lett·2005
8-other
An update on psychiatric disorders in relation to dental treatment.
PMID 15554055·Dent Update·2004
6-review
An investigation of the effect on 27-gauge needle tips following a single local anaesthetic injection.
PMID 14558202·Dent Update·2003
8-other
The kinase inhibitor STI571 reverses the Bcr-Abl induced point mutation frequencies observed in pre-leukemic P190(Bcr-Abl) transgenic mice.
PMID 12363470·Leuk Res·2002
7-preclinical
Synthesis and antifungal activity of the 2,2,5-tetrahydrofuran regioisomers of SCH 51048.
PMID 12067550·Bioorg Med Chem Lett·2002
8-other
Data courtesy of the U.S. National Library of Medicine (NLM). Ltrl is not affiliated with or endorsed by NLM.
Contact & Hours
- Address
- 3400 SPRUCE STREET
PHILADELPHIA, PA 19104 - Phone
- (215) 662-6503
Quick Facts
- NPI
- 1154771160
- Entity Type
- Individual
- Gender
- Female
- Medicare
- Accepted
- Specialties
- 1
- Locations
- 1
- Years in Practice
- 16
- Publications
- 20
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