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SHARI LECKER, M.D.
M.D.
Specialist
NPI: 1164415840Individual
Specialties, Licenses & Credentials
SpecialistPrimary
Specialist
Code: 174400000X
051421(MA)
Research & Publications (20)
Protein degradation by the ubiquitin-proteasome pathway in normal and disease states.
PMID 16738015·J Am Soc Nephrol·2006
6-review
Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression.
PMID 14718385·FASEB J·2004
4-observational
Ubiquitin-protein ligases in muscle wasting: multiple parallel pathways?
PMID 12690258·Curr Opin Clin Nutr Metab Care·2003
6-review
Slowing muscle atrophy: putting the brakes on protein breakdown.
PMID 12482881·J Physiol·2002
7-preclinical
Statin-induced muscle damage and atrogin-1 induction is the result of a geranylgeranylation defect.
PMID 19406843·FASEB J·2009
7-preclinical
Calpain activity and muscle wasting in sepsis.
PMID 18492780·Am J Physiol Endocrinol Metab·2008
6-review
Jade-1 inhibits Wnt signalling by ubiquitylating beta-catenin and mediates Wnt pathway inhibition by pVHL.
PMID 18806787·Nat Cell Biol·2008
7-preclinical
Molecular basis for statin-induced muscle toxicity: implications and possibilities.
PMID 18681786·Pharmacogenomics·2008
6-review
Dexamethasone and corticosterone induce similar, but not identical, muscle wasting responses in cultured L6 and C2C12 myotubes.
PMID 18615595·J Cell Biochem·2008
4-observational
Electrolyte-free water clearance: a key to the diagnosis of hypernatremia in resolving acute renal failure.
PMID 18180873·Clin Exp Nephrol·2008
5-case
Rapid disuse and denervation atrophy involve transcriptional changes similar to those of muscle wasting during systemic diseases.
PMID 17116744·FASEB J·2007
7-preclinical
The muscle-specific ubiquitin ligase atrogin-1/MAFbx mediates statin-induced muscle toxicity.
PMID 17992259·J Clin Invest·2007
7-preclinical
Atrophy-related ubiquitin ligases atrogin-1 and MuRF-1 are associated with uterine smooth muscle involution in the postpartum period.
PMID 17008454·Am J Physiol Regul Integr Comp Physiol·2007
7-preclinical
FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells.
PMID 18054316·Cell Metab·2007
7-preclinical
PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription.
PMID 17053067·Proc Natl Acad Sci U S A·2006
7-preclinical
The FOXO3a transcription factor regulates cardiac myocyte size downstream of AKT signaling.
PMID 15781459·J Biol Chem·2005
7-preclinical
Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy.
PMID 15109499·Cell·2004
7-preclinical
[Elucidation and treatment of patients with acute chest pain in 16 Danish hospitals--the LysAMI project].
PMID 14579554·Ugeskr Laeger·2003
8-other
TNF-alpha increases ubiquitin-conjugating activity in skeletal muscle by up-regulating UbcH2/E220k.
PMID 12773487·FASEB J·2003
7-preclinical
Data courtesy of the U.S. National Library of Medicine (NLM). Ltrl is not affiliated with or endorsed by NLM.
Contact & Hours
- Address
- 101 MAIN ST, SUITE 201
MEDFORD, MA 02155 - Phone
- (781) 396-1288
Quick Facts
- NPI
- 1164415840
- Entity Type
- Individual
- Gender
- Female
- Medicare
- Not confirmed
- Specialties
- 1
- Locations
- 1
- Publications
- 20
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