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TIMOTHY ROCHE, PHARMD
PHARMD
Pharmacist
NPI: 1225202443Individual
Specialties, Licenses & Credentials
PharmacistPrimary
Pharmacist
Code: 183500000X
29211(TN)
Research & Publications (20)
Critical role of specific ions for ligand-induced changes regulating pyruvate dehydrogenase kinase isoform 2.
PMID 18220414·Biochemistry·2008
8-other
Structures of the human pyruvate dehydrogenase complex cores: a highly conserved catalytic center with flexible N-terminal domains.
PMID 18184588·Structure·2008
8-other
Specific ion influences on self-association of pyruvate dehydrogenase kinase isoform 2 (PDHK2), binding of PDHK2 to the L2 lipoyl domain, and effects of the lipoyl group-binding site inhibitor, Nov3r.
PMID 18220415·Biochemistry·2008
8-other
The effects of high shear blending on alpha-lactose monohydrate.
PMID 17398047·Int J Pharm·2007
8-other
Pyruvate dehydrogenase kinase regulatory mechanisms and inhibition in treating diabetes, heart ischemia, and cancer.
PMID 17310282·Cell Mol Life Sci·2007
6-review
Ligand-induced effects on pyruvate dehydrogenase kinase isoform 2.
PMID 16517984·J Biol Chem·2006
8-other
Regulatory roles of the N-terminal domain based on crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands.
PMID 16401071·Biochemistry·2006
8-other
Formation of a complex of the catalytic subunit of pyruvate dehydrogenase phosphatase isoform 1 (PDP1c) and the L2 domain forms a Ca2+ binding site and captures PDP1c as a monomer.
PMID 15554715·Biochemistry·2004
7-preclinical
Organization of the cores of the mammalian pyruvate dehydrogenase complex formed by E2 and E2 plus the E3-binding protein and their capacities to bind the E1 and E3 components.
PMID 14638692·J Biol Chem·2004
8-other
Pyruvate dehydrogenase kinase isoform 2 activity stimulated by speeding up the rate of dissociation of ADP.
PMID 15491151·Biochemistry·2004
8-other
Pyruvate dehydrogenase kinase isoform 2 activity limited and further inhibited by slowing down the rate of dissociation of ADP.
PMID 15491150·Biochemistry·2004
8-other
AZD7545 is a selective inhibitor of pyruvate dehydrogenase kinase 2.
PMID 14641019·Biochem Soc Trans·2003
7-preclinical
Autoreactivity to lipoate and a conjugated form of lipoate in primary biliary cirrhosis.
PMID 14724823·Gastroenterology·2003
7-preclinical
Facilitated interaction between the pyruvate dehydrogenase kinase isoform 2 and the dihydrolipoyl acetyltransferase.
PMID 12816949·J Biol Chem·2003
8-other
Essential roles of lipoyl domains in the activated function and control of pyruvate dehydrogenase kinases and phosphatase isoform 1.
PMID 12631265·Eur J Biochem·2003
6-review
Structural requirements within the lipoyl domain for the Ca2+-dependent binding and activation of pyruvate dehydrogenase phosphatase isoform 1 or its catalytic subunit.
PMID 11842080·J Biol Chem·2002
7-preclinical
Distinct regulatory properties of pyruvate dehydrogenase kinase and phosphatase isoforms.
PMID 11642366·Prog Nucleic Acid Res Mol Biol·2001
6-review
Reaction mechanism for mammalian pyruvate dehydrogenase using natural lipoyl domain substrates.
PMID 11368334·Arch Biochem Biophys·2001
7-preclinical
Data courtesy of the U.S. National Library of Medicine (NLM). Ltrl is not affiliated with or endorsed by NLM.
Contact & Hours
- Address
- 2485 MEMORIAL BLVD
MURFREESBORO, TN 37129 - Phone
- (615) 904-9907
Quick Facts
- NPI
- 1225202443
- Entity Type
- Individual
- Gender
- Male
- Medicare
- Not confirmed
- Specialties
- 1
- Locations
- 1
- Publications
- 20
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