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LORNE TRIMBLE, DMD, MD
DMD, MD
Oral and Maxillofacial Surgery (Dentist)
NPI: 1255337853Individual
Specialties, Licenses & Credentials
Oral and Maxillofacial Surgery (Dentist)Primary
Dentist — Oral and Maxillofacial Surgery
Code: 1223S0112X
5877(WA)
Research & Publications (20)
Identification of novel metabolites of colchicine in rat bile facilitated by enhanced online radiometric detection.
PMID 18227142·Drug Metab Dispos·2008
4-observational
Discovery of a potent and selective prostaglandin D2 receptor antagonist, [(3R)-4-(4-chloro-benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-acetic acid (MK-0524).
PMID 17300164·J Med Chem·2007
7-preclinical
Isolation and structure elucidation by LC-MS-SPE/NMR: PR toxin- and cuspidatol-related eremophilane sesquiterpenes from Penicillium roqueforti.
PMID 17253863·J Nat Prod·2007
8-other
Metabolic activation of indole-containing prostaglandin D2 receptor 1 antagonists: impacts of glutathione trapping and glucuronide conjugation on covalent binding.
PMID 17418572·Bioorg Med Chem Lett·2007
7-preclinical
In vitro biotransformations of the prostaglandin D2 (DP) antagonist MK-0524 and synthesis of metabolites.
PMID 17095220·Bioorg Med Chem Lett·2007
7-preclinical
Interspecies in vitro metabolism of the phosphodiesterase-4 (PDE4) inhibitor L-454,560.
PMID 16705670·J Mass Spectrom·2006
4-observational
Structure-activity relationship studies on ortho-substituted cinnamic acids, a new class of selective EP(3) antagonists.
PMID 15664806·Bioorg Med Chem Lett·2005
8-other
Discovery of a substituted 8-arylquinoline series of PDE4 inhibitors: structure-activity relationship, optimization, and identification of a highly potent, well tolerated, PDE4 inhibitor.
PMID 16168647·Bioorg Med Chem Lett·2005
7-preclinical
Discovery, biosynthesis, and structure elucidation of metabolites of a doping agent and a direct analogue, tetrahydrogestrinone and gestrinone, using human hepatocytes.
PMID 15889905·Anal Chem·2005
8-other
Association of SULT1A1 phenotype and genotype with prostate cancer risk in African-Americans and Caucasians.
PMID 14973106·Cancer Epidemiol Biomarkers Prev·2004
4-observational
Catalytic inactivation of protein tyrosine phosphatase CD45 and protein tyrosine phosphatase 1B by polyaromatic quinones.
PMID 15065873·Biochemistry·2004
8-other
T cell costimulation through CD28 depends on induction of the Bcl-xgamma isoform: analysis of Bcl-xgamma-deficient mice.
PMID 12093873·J Exp Med·2002
7-preclinical
Fas-dependent elimination of nonselected CD8 cells and lpr disease.
PMID 11994447·J Immunol·2002
7-preclinical
Diversity in the oxidation of substrates by cytochrome P450 2D6: lack of an obligatory role of aspartate 301-substrate electrostatic bonding.
PMID 12206675·Biochemistry·2002
8-other
Investigation of the in vitro metabolism profile of a phosphodiesterase-IV inhibitor, CDP-840: leading to structural optimization.
PMID 11181489·Drug Metab Dispos·2001
7-preclinical
In vitro metabolism considerations, including activity testing of metabolites, in the discovery and selection of the COX-2 inhibitor etoricoxib (MK-0663).
PMID 11327589·Bioorg Med Chem Lett·2001
8-other
In vitro metabolism of the COX-2 inhibitor DFU, including a novel glutathione adduct rearomatization.
PMID 11302928·Drug Metab Dispos·2001
7-preclinical
Gamma-aminobutyric acid type B receptors with specific heterodimer composition and postsynaptic actions in hippocampal neurons are targets of anticonvulsant gabapentin action.
PMID 11125035·Mol Pharmacol·2001
7-preclinical
Data courtesy of the U.S. National Library of Medicine (NLM). Ltrl is not affiliated with or endorsed by NLM.
Contact & Hours
- Address
- 1370 116TH AVE NE, STE 101
BELLEVUE, WA 98004 - Phone
- (425) 453-6975
Quick Facts
- NPI
- 1255337853
- Entity Type
- Individual
- Gender
- Male
- Medicare
- Not confirmed
- Specialties
- 1
- Locations
- 1
- Publications
- 20
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