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ERIC SERGIENKO, MD

MD

Emergency Medicine Physician

NPI: 1255595179Individual

Specialties, Licenses & Credentials

Emergency Medicine PhysicianPrimary

Emergency Medicine

Code: 207P00000X

A55033(CA)

Research & Publications (16)

Identification and characterization of novel tissue-nonspecific alkaline phosphatase inhibitors with diverse modes of action.
PMID 19556612·J Biomol Screen·2009
7-preclinical
Yeast pyruvate decarboxylase tetramers can dissociate into dimers along two interfaces. Hybrids of low-activity D28A (or D28N) and E477Q variants, with substitution of adjacent active center acidic groups from different subunits, display restored activity.
PMID 11994012·Biochemistry·2002
8-other
New model for activation of yeast pyruvate decarboxylase by substrate consistent with the alternating sites mechanism: demonstration of the existence of two active forms of the enzyme.
PMID 11900538·Biochemistry·2002
8-other
Engineering a leucine zipper-TRAIL homotrimer with improved cytotoxicity in tumor cells.
PMID 19509255·Mol Cancer Ther·2009
7-preclinical
Triple hybrids of steroids, spiroketals, and oligopeptides as new biomolecular chimeras.
PMID 19067551·Org Lett·2009
8-other
Design and synthesis of pyrazole derivatives as potent and selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP).
PMID 19038545·Bioorg Med Chem Lett·2009
8-other
A TR3/Nur77 peptide-based high-throughput fluorescence polarization screen for small molecule Bcl-B inhibitors.
PMID 18626112·J Biomol Screen·2008
8-other
Reconstituted NALP1 inflammasome reveals two-step mechanism of caspase-1 activation.
PMID 17349957·Mol Cell·2007
8-other
Multiple modes of active center communication in thiamin diphosphate-dependent enzymes.
PMID 16171318·Acc Chem Res·2005
8-other
[Bowel dysfunctional microflora: clinical significance and prospects for its therapy].
PMID 14556552·Eksp Klin Gastroenterol·2003
6-review
Structural and kinetic analysis of catalysis by a thiamin diphosphate-dependent enzyme, benzoylformate decarboxylase.
PMID 12590569·Biochemistry·2003
8-other
Spectroscopic evidence for participation of the 1',4'-imino tautomer of thiamin diphosphate in catalysis by yeast pyruvate decarboxylase.
PMID 12406703·Bioorg Chem·2002
8-other
Catalytic acid-base groups in yeast pyruvate decarboxylase. 3. A steady-state kinetic model consistent with the behavior of both wild-type and variant enzymes at all relevant pH values.
PMID 11412092·Biochemistry·2001
4-observational
Catalytic acid-base groups in yeast pyruvate decarboxylase. 2. Insights into the specific roles of D28 and E477 from the rates and stereospecificity of formation of carboligase side products.
PMID 11412091·Biochemistry·2001
8-other
Catalytic acid-base groups in yeast pyruvate decarboxylase. 1. Site-directed mutagenesis and steady-state kinetic studies on the enzyme with the D28A, H114F, H115F, and E477Q substitutions.
PMID 11412090·Biochemistry·2001
4-observational
Spectroscopic detection of transient thiamin diphosphate-bound intermediates on benzoylformate decarboxylase.
PMID 11076527·Biochemistry·2000
8-other

Data courtesy of the U.S. National Library of Medicine (NLM). Ltrl is not affiliated with or endorsed by NLM.

Contact & Hours

Address
250 VANDENBERG ST, US NORTHERN COMMAND SURGEON'S OFFICE
COLORADO SPRINGS, CO 80914

Location

Practice Location

250 VANDENBERG ST, COLORADO SPRINGS, CO
(703) 554-0042

Quick Facts

NPI
1255595179
Entity Type
Individual
Gender
Male
Medicare
Not confirmed
Specialties
1
Locations
1
Publications
16

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