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JAY KARPEN, MD
MD
Pain Medicine Physician
NPI: 1386613131Individual
Specialties, Licenses & Credentials
Pain Medicine PhysicianPrimary
Pain Medicine — Pain Medicine
Code: 208VP0000X
MD040757L(PA)
Research & Publications (20)
High-resolution measurements of cyclic adenosine monophosphate signals in 3D microdomains.
PMID 15988052·Methods Mol Biol·2005
7-preclinical
Resolution of cAMP signals in three-dimensional microdomains using novel, real-time sensors.
PMID 15633600·Proc West Pharmacol Soc·2004
8-other
Ion channel structure and the promise of bacteria: cyclic nucleotide-gated channels in the queue.
PMID 15337818·J Gen Physiol·2004
8-other
Ion channels: does each subunit do something on its own?
PMID 12151225·Trends Biochem Sci·2002
6-review
Covalent tethering of ligands to retinal rod cyclic nucleotide-gated channels: binding site structure and allosteric mechanism.
PMID 10736739·Methods Enzymol·2000
7-preclinical
Block of cyclic nucleotide-gated channels by tetracaine derivatives: role of apolar interactions at two distinct locations.
PMID 18055205·Bioorg Med Chem Lett·2008
7-preclinical
Cellular mechanisms underlying prostaglandin-induced transient cAMP signals near the plasma membrane of HEK-293 cells.
PMID 16899551·Am J Physiol Cell Physiol·2007
8-other
Novel N7- and N1-substituted cGMP derivatives are potent activators of cyclic nucleotide-gated channels.
PMID 17665892·J Med Chem·2007
8-other
The pharmacology of cyclic nucleotide-gated channels: emerging from the darkness.
PMID 17073662·Curr Pharm Des·2006
6-review
Interplay between PIP3 and calmodulin regulation of olfactory cyclic nucleotide-gated channels.
PMID 17032767·Proc Natl Acad Sci U S A·2006
7-preclinical
Modifications to the tetracaine scaffold produce cyclic nucleotide-gated channel blockers with widely varying efficacies.
PMID 16134947·J Med Chem·2005
7-preclinical
High-throughput screening of phosphodiesterase activity in living cells.
PMID 15988054·Methods Mol Biol·2005
7-preclinical
Functional role of lipid raft microdomains in cyclic nucleotide-gated channel activation.
PMID 14978228·Mol Pharmacol·2004
7-preclinical
A multiply charged tetracaine derivative blocks cyclic nucleotide-gated channels at subnanomolar concentrations.
PMID 12525153·Biochemistry·2003
4-observational
Review article: cyclic AMP sensors in living cells: what signals can they actually measure?
PMID 12449769·Ann Biomed Eng·2002
6-review
Probing the interactions between cAMP and cGMP in cyclic nucleotide-gated channels using covalently tethered ligands.
PMID 11141082·Biochemistry·2001
7-preclinical
A uniform extracellular stimulus triggers distinct cAMP signals in different compartments of a simple cell.
PMID 11606735·Proc Natl Acad Sci U S A·2001
8-other
In vivo assessment of local phosphodiesterase activity using tailored cyclic nucleotide-gated channels as cAMP sensors.
PMID 11429444·J Gen Physiol·2001
7-preclinical
Data courtesy of the U.S. National Library of Medicine (NLM). Ltrl is not affiliated with or endorsed by NLM.
Contact & Hours
- Address
- 3402 WASHINGTON RD
MC MURRAY, PA 15317 - Phone
- (724) 942-5188
Quick Facts
- NPI
- 1386613131
- Entity Type
- Individual
- Gender
- Male
- Medicare
- Not confirmed
- Specialties
- 1
- Locations
- 1
- Publications
- 20
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