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NORMAN IKEMOTO, MD
MD
Diagnostic Radiology Physician
NPI: 1427038561Individual
Specialties, Licenses & Credentials
Diagnostic Radiology PhysicianPrimary
Radiology — Diagnostic Radiology
Code: 2085R0202X
2815(HI)
Research & Publications (20)
Highly diastereoselective heterogeneously catalyzed hydrogenation of enamines for the synthesis of chiral beta-amino acid derivatives.
PMID 15012124·J Am Chem Soc·2004
8-other
Amyloid-β protein impairs Ca2+ release and contractility in skeletal muscle.
PMID 19108934·Neurobiol Aging·2010
4-observational
Defective domain-domain interactions within the ryanodine receptor as a critical cause of diastolic Ca2+ leak in failing hearts.
PMID 18996969·Cardiovasc Res·2009
7-preclinical
Alternative splicing of RyR1 alters the efficacy of skeletal EC coupling.
PMID 19131108·Cell Calcium·2009
7-preclinical
Dantrolene, a therapeutic agent for malignant hyperthermia, markedly improves the function of failing cardiomyocytes by stabilizing interdomain interactions within the ryanodine receptor.
PMID 19460614·J Am Coll Cardiol·2009
4-observational
Defective regulation of the ryanodine receptor induces hypertrophy in cardiomyocytes.
PMID 19284993·Biochem Biophys Res Commun·2009
7-preclinical
Interaction of the Lys(3614)-Asn(3643) calmodulin-binding domain with the Cys(4114)-Asn(4142) region of the type 1 ryanodine receptor is involved in the mechanism of Ca2+/agonist-induced channel activation.
PMID 18171325·Biochem J·2008
7-preclinical
Identification of target domains of the cardiac ryanodine receptor to correct channel disorder in failing hearts.
PMID 18227387·Circulation·2008
7-preclinical
A domain peptide of the cardiac ryanodine receptor regulates channel sensitivity to luminal Ca2+ via cytoplasmic Ca2+ sites.
PMID 18038129·Eur Biophys J·2008
7-preclinical
Peptide probe study of the role of interaction between the cytoplasmic and transmembrane domains of the ryanodine receptor in the channel regulation mechanism.
PMID 17361990·Biochemistry·2007
7-preclinical
Scavenging free radicals by low-dose carvedilol prevents redox-dependent Ca2+ leak via stabilization of ryanodine receptor in heart failure.
PMID 17448375·J Am Coll Cardiol·2007
7-preclinical
Discovery and synthesis of HIV integrase inhibitors: development of potent and orally bioavailable N-methyl pyrimidones.
PMID 17824681·J Med Chem·2007
7-preclinical
Postulated role of interdomain interaction between regions 1 and 2 within type 1 ryanodine receptor in the pathogenesis of porcine malignant hyperthermia.
PMID 17107340·Biochem J·2007
7-preclinical
Malignant hyperthermia mutation sites in the Leu2442-Pro2477 (DP4) region of RyR1 (ryanodine receptor 1) are clustered in a structurally and functionally definable area.
PMID 16958617·Biochem J·2007
7-preclinical
The ryanodine receptor pore blocker neomycin also inhibits channel activity via a previously undescribed high-affinity Ca(2+) binding site.
PMID 17879109·J Membr Biol·2007
7-preclinical
Effects of peptide C corresponding to the Glu724-Pro760 region of the II-III loop of the DHP (dihydropyridine) receptor alpha1 subunit on the domain- switch-mediated activation of RyR1 (ryanodine receptor 1) Ca2+ channels.
PMID 16302848·Biochem J·2006
7-preclinical
Role of the Met3534-Ala4271 region of the ryanodine receptor in the regulation of Ca2+ release induced by calmodulin binding domain peptide.
PMID 16387763·Biophys J·2006
7-preclinical
The RyR2 central domain peptide DPc10 lowers the threshold for spontaneous Ca2+ release in permeabilized cardiomyocytes.
PMID 16624262·Cardiovasc Res·2006
7-preclinical
Correction of defective interdomain interaction within ryanodine receptor by antioxidant is a new therapeutic strategy against heart failure.
PMID 16330705·Circulation·2005
7-preclinical
Data courtesy of the U.S. National Library of Medicine (NLM). Ltrl is not affiliated with or endorsed by NLM.
Contact & Hours
- Address
- 640 ULUKAHIKI ST
KAILUA, HI 96734 - Phone
- (808) 263-5166
Quick Facts
- NPI
- 1427038561
- Entity Type
- Individual
- Gender
- Male
- Medicare
- Not confirmed
- Specialties
- 1
- Locations
- 1
- Publications
- 20
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