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JOHN HUTZLER, M.D.
M.D.
Obstetrics & Gynecology Physician
NPI: 1457393480Individual
Specialties, Licenses & Credentials
Obstetrics & Gynecology PhysicianPrimary
Obstetrics & Gynecology
Code: 207V00000X
35033211H(OH)
Research & Publications (20)
Is 1-aminobenzotriazole an appropriate in vitro tool as a nonspecific cytochrome P450 inactivator?
PMID 18936109·Drug Metab Dispos·2009
8-other
Mechanism-based inactivation of cytochrome P450 2C9 by tienilic acid and (+/-)-suprofen: a comparison of kinetics and probe substrate selection.
PMID 18838506·Drug Metab Dispos·2009
4-observational
Assessment of the metabolism and intrinsic reactivity of a novel catechol metabolite.
PMID 18407675·Chem Res Toxicol·2008
7-preclinical
Membrane association is a determinant for substrate recognition by PMT4 protein O-mannosyltransferases.
PMID 17470820·Proc Natl Acad Sci U S A·2007
8-other
Visible spectra of type II cytochrome P450-drug complexes: evidence that "incomplete" heme coordination is common.
PMID 17251307·Drug Metab Dispos·2007
4-observational
Inhibition of cytochrome P450 3A4 by a pyrimidineimidazole: Evidence for complex heme interactions.
PMID 17173379·Chem Res Toxicol·2006
8-other
Atmospheric pressure desorption/ionization on silicon ion trap mass spectrometry applied to the quantitation of midazolam in rat plasma and determination of midazolam 1'-hydroxylation kinetics in human liver microsomes.
PMID 17117443·Rapid Commun Mass Spectrom·2006
7-preclinical
Influence of fluorescent probe size and cytochrome b5 on drug-drug interactions in CYP2C9.
PMID 16490777·J Biomol Screen·2006
8-other
Catalytic turnover of pyrene by CYP3A4: evidence that cytochrome b5 directly induces positive cooperativity.
PMID 15910734·Arch Biochem Biophys·2005
8-other
Induction and inhibition of cytochromes P450 by the St. John's wort constituent hyperforin in human hepatocyte cultures.
PMID 15100173·Drug Metab Dispos·2004
4-observational
Mechanism-based inactivation of cytochrome P450 2D6 by 1-[(2-ethyl-4-methyl-1H-imidazol-5-yl)methyl]- 4-[4-(trifluoromethyl)-2-pyridinyl]piperazine: kinetic characterization and evidence for apoprotein adduction.
PMID 14967005·Chem Res Toxicol·2004
8-other
Effect of carbonate anion on cytochrome P450 2D6-mediated metabolism in vitro: the potential role of multiple oxygenating species.
PMID 12941298·Arch Biochem Biophys·2003
4-observational
In vitro metabolism of clindamycin in human liver and intestinal microsomes.
PMID 12814964·Drug Metab Dispos·2003
4-observational
Inhibition of cytochrome P450 2D6: structure-activity studies using a series of quinidine and quinine analogues.
PMID 12703961·Chem Res Toxicol·2003
4-observational
Activation of cytochrome P450 2C9-mediated metabolism: mechanistic evidence in support of kinetic observations.
PMID 12559973·Arch Biochem Biophys·2003
8-other
Activation of CYP2C9-mediated metabolism by a series of dapsone analogs: kinetics and structural requirements.
PMID 12386124·Drug Metab Dispos·2002
8-other
Polymorphic variants (CYP2C9*3 and CYP2C9*5) and the F114L active site mutation of CYP2C9: effect on atypical kinetic metabolism profiles.
PMID 11901091·Drug Metab Dispos·2002
8-other
Minimal in vivo activation of CYP2C9-mediated flurbiprofen metabolism by dapsone.
PMID 11457649·Eur J Pharm Sci·2001
8-other
Dapsone activation of CYP2C9-mediated metabolism: evidence for activation of multiple substrates and a two-site model.
PMID 11408370·Drug Metab Dispos·2001
8-other
Data courtesy of the U.S. National Library of Medicine (NLM). Ltrl is not affiliated with or endorsed by NLM.
Contact & Hours
- Address
- 121 NORTHWEST AVE
TALLMADGE, OH 44278 - Phone
- (330) 633-1352
Quick Facts
- NPI
- 1457393480
- Entity Type
- Individual
- Gender
- Male
- Medicare
- Not confirmed
- Specialties
- 1
- Locations
- 1
- Publications
- 20
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