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GARY MCGAUGHEY, D.M.D.
D.M.D.
General Practice Dentistry
NPI: 1457446213Individual
Specialties, Licenses & Credentials
General Practice DentistryPrimary
Dentist — General Practice
Code: 1223G0001X
D4069(OR)
Research & Publications (20)
Beta-secretase (BACE-1) inhibitors: accounting for 10s loop flexibility using rigid active sites.
PMID 17112725·Bioorg Med Chem Lett·2007
8-other
Scoring of KDR kinase inhibitors: using interaction energy as a guide for ranking.
PMID 17004013·Mol Divers·2006
8-other
Progress towards the development of a HIV-1 gp41-directed vaccine.
PMID 15078183·Curr HIV Res·2004
6-review
HIV-1 vaccine development: constrained peptide immunogens show improved binding to the anti-HIV-1 gp41 MAb.
PMID 12641452·Biochemistry·2003
8-other
Conformational analysis of N,N-disubstituted-1,4-diazepane orexin receptor antagonists and implications for receptor binding.
PMID 19406641·Bioorg Med Chem Lett·2009
8-other
Evolution of tertiary carbinamine BACE-1 inhibitors: Abeta reduction in rhesus CSF upon oral dosing.
PMID 19085994·ChemMedChem·2009
7-preclinical
Identification of a small molecule beta-secretase inhibitor that binds without catalytic aspartate engagement.
PMID 19036583·Bioorg Med Chem Lett·2009
8-other
First demonstration of cerebrospinal fluid and plasma A beta lowering with oral administration of a beta-site amyloid precursor protein-cleaving enzyme 1 inhibitor in nonhuman primates.
PMID 18854490·J Pharmacol Exp Ther·2009
7-preclinical
Discovery of 3-{5-[(6-amino-1H-pyrazolo[3,4-b]pyridine-3-yl)methoxy]-2-chlorophenoxy}-5-chlorobenzonitrile (MK-4965): a potent, orally bioavailable HIV-1 non-nucleoside reverse transcriptase inhibitor with improved potency against key mutant viruses.
PMID 18826204·J Med Chem·2008
7-preclinical
Discovery and X-ray crystallographic analysis of a spiropiperidine iminohydantoin inhibitor of beta-secretase.
PMID 18811140·J Med Chem·2008
8-other
The design and synthesis of diaryl ether second generation HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) with enhanced potency versus key clinical mutations.
PMID 18396399·Bioorg Med Chem Lett·2008
8-other
Novel indole-3-sulfonamides as potent HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs).
PMID 18083561·Bioorg Med Chem Lett·2008
8-other
Strategies toward improving the brain penetration of macrocyclic tertiary carbinamine BACE-1 inhibitors.
PMID 17827011·Bioorg Med Chem Lett·2007
8-other
Design, synthesis, and SAR of macrocyclic tertiary carbinamine BACE-1 inhibitors.
PMID 17482814·Bioorg Med Chem Lett·2007
8-other
Design and synthesis of 2,3,5-substituted imidazolidin-4-one inhibitors of BACE-1.
PMID 17458843·ChemMedChem·2007
8-other
Discovery and SAR of isonicotinamide BACE-1 inhibitors that bind beta-secretase in a N-terminal 10s-loop down conformation.
PMID 17257835·Bioorg Med Chem Lett·2007
7-preclinical
Evaluating scoring functions for docking and designing beta-secretase inhibitors.
PMID 17107793·Bioorg Med Chem Lett·2007
8-other
Discovery of oxadiazoyl tertiary carbinamine inhibitors of beta-secretase (BACE-1).
PMID 17149856·J Med Chem·2006
8-other
Web enabling technology for the design, enumeration, optimization and tracking of compound libraries.
PMID 16101417·Curr Top Med Chem·2005
6-review
The discovery of N-(1,3-thiazol-2-yl)pyridin-2-amines as potent inhibitors of KDR kinase.
PMID 15125964·Bioorg Med Chem Lett·2004
8-other
Data courtesy of the U.S. National Library of Medicine (NLM). Ltrl is not affiliated with or endorsed by NLM.
Contact & Hours
- Address
- 11507 SW SHILO LANE
PORTLAND, OR 97225 - Phone
- (503) 626-1730
Quick Facts
- NPI
- 1457446213
- Entity Type
- Individual
- Gender
- Male
- Medicare
- Not confirmed
- Specialties
- 1
- Locations
- 1
- Publications
- 20
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