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WILLIAM SHEFFIELD, MD
MD
Orthopaedic Surgery Physician
NPI: 1457459000Individual
Specialties, Licenses & Credentials
Orthopaedic Surgery PhysicianPrimary
Orthopaedic Surgery
Code: 207X00000X
MD2005-0112(NM)
Research & Publications (20)
A long-lasting, plasmin-activatable thrombin inhibitor aids clot lysis in vitro and does not promote bleeding in vivo.
PMID 19404540·Thromb Haemost·2009
7-preclinical
Addition of a sequence from alpha2-antiplasmin transforms human serum albumin into a blood clot component that speeds clot lysis.
PMID 19257897·BMC Biotechnol·2009
7-preclinical
Combined administration of barbourin--albumin and hirudin--albumin fusion proteins limits fibrin(ogen) deposition on the rabbit balloon-injured aorta.
PMID 16478628·Thromb Res·2007
7-preclinical
The appended tail region of heparin cofactor II and additional reactive centre loop mutations combine to increase the reactivity and specificity of alpha1-proteinase inhibitor M358R for thrombin.
PMID 18000606·Thromb Haemost·2007
7-preclinical
Investigating serpin-enzyme complex formation and stability via single and multiple residue reactive centre loop substitutions in heparin cofactor II.
PMID 15869786·Thromb Res·2006
8-other
Detection of antibodies reacting with the antithetical duffy blood group antigens Fy(a) and Fy(b) using recombinant fusion proteins containing the duffy extracellular domain.
PMID 17113828·Transfus Apher Sci·2006
8-other
The transferable tail: fusion of the N-terminal acidic extension of heparin cofactor II to alpha1-proteinase inhibitor M358R specifically increases the rate of thrombin inhibition.
PMID 16981704·Biochemistry·2006
8-other
Molecular cloning and functional expression of rabbit alpha2-antiplasmin.
PMID 16651871·Blood Coagul Fibrinolysis·2006
7-preclinical
Recombinant albumins containing additional peptide sequences smaller than barbourin retain the ability of barbourin-albumin to inhibit platelet aggregation.
PMID 15886809·Thromb Haemost·2005
7-preclinical
An important role for the activation peptide domain in controlling factor IX levels in the blood of haemophilia B mice.
PMID 16411385·Thromb Haemost·2005
4-observational
Blood group biochemistry: a canadian blood services research and development symposium.
PMID 16214019·Transfus Med Rev·2005
8-other
Fusion to albumin as a means to slow the clearance of small therapeutic proteins using the Pichia pastoris expression system: a case study.
PMID 16082032·Methods Mol Biol·2005
8-other
Full or partial substitution of the reactive center loop of alpha-1-proteinase inhibitor by that of heparin cofactor II: P1 Arg is required for maximal thrombin inhibition.
PMID 15544357·Biochemistry·2004
8-other
Effects of genetic fusion of factor IX to albumin on in vivo clearance in mice and rabbits.
PMID 15287951·Br J Haematol·2004
7-preclinical
Heparin cofactor II is more sensitive than antithrombin to secretory impairment arising from mutations introduced into its carboxy-terminal region.
PMID 15115672·Thromb Res·2004
4-observational
A covalently linked recombinant albumin dimer is more rapidly cleared in vivo than are wild-type and mutant C34A albumin.
PMID 14966467·J Lab Clin Med·2004
7-preclinical
Altering heparin cofactor II at VAL439 (P6) either impairs inhibition of thrombin or confers elastase resistance.
PMID 12152684·Thromb Haemost·2002
8-other
Modification of clearance of therapeutic and potentially therapeutic proteins.
PMID 12769661·Curr Drug Targets Cardiovasc Haematol Disord·2001
6-review
A barbourin-albumin fusion protein that is slowly cleared in vivo retains the ability to inhibit platelet aggregation in vitro.
PMID 11583325·Thromb Haemost·2001
7-preclinical
Data courtesy of the U.S. National Library of Medicine (NLM). Ltrl is not affiliated with or endorsed by NLM.
Contact & Hours
- Address
- 32 TURKEY CANYON ROAD
CARLSBAD, NM 88220 - Phone
- (575) 981-2486
Quick Facts
- NPI
- 1457459000
- Entity Type
- Individual
- Gender
- Male
- Medicare
- Not confirmed
- Specialties
- 1
- Locations
- 1
- Publications
- 20
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