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JOHN LETTERIO, MD
MD
Pediatric Hematology & Oncology Physician
NPI: 1467589739Individual
Specialties, Licenses & Credentials
Pediatric Hematology & Oncology PhysicianPrimary
Pediatrics — Pediatric Hematology-Oncology
Code: 2080P0207X
35-089599(OH)D0039985(MD)
Research & Publications (20)
Transforming growth factor-beta1 sensitivity is altered in Abl-Myc- and Raf-Myc-induced mouse pre-B-cell tumors.
PMID 16945999·Stem Cells·2006
7-preclinical
TGF beta-mediated BIM expression and apoptosis are regulated through SMAD3-dependent expression of the MAPK phosphatase MKP2.
PMID 18704116·EMBO Rep·2008
7-preclinical
Human neuroblastoma cells rapidly enter cell cycle arrest and apoptosis following exposure to C-28 derivatives of the synthetic triterpenoid CDDO.
PMID 18277094·Cancer Biol Ther·2008
8-other
TGF-beta 1 inhibition of IFN-gamma-induced signaling and Th1 gene expression in CD4+ T cells is Smad3 independent but MAP kinase dependent.
PMID 17403540·Mol Immunol·2007
7-preclinical
Yeast zymosan, a stimulus for TLR2 and dectin-1, induces regulatory antigen-presenting cells and immunological tolerance.
PMID 16543948·J Clin Invest·2006
4-observational
The synthetic triterpenoid CDDO-Imidazolide suppresses STAT phosphorylation and induces apoptosis in myeloma and lung cancer cells.
PMID 16857804·Clin Cancer Res·2006
8-other
Smad4 signalling in T cells is required for suppression of gastrointestinal cancer.
PMID 16791201·Nature·2006
7-preclinical
Notch1 mutations are important for leukemic transformation in murine models of precursor-T leukemia/lymphoma.
PMID 16282337·Blood·2006
7-preclinical
TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells.
PMID 15809351·J Exp Med·2005
4-observational
TGF-beta1 inhibits T-bet induction by IFN-gamma in murine CD4+ T cells through the protein tyrosine phosphatase Src homology region 2 domain-containing phosphatase-1.
PMID 16237056·J Immunol·2005
7-preclinical
TGF-beta1 production by CD4+ CD25+ regulatory T cells is not essential for suppression of intestinal inflammation.
PMID 16180248·Eur J Immunol·2005
7-preclinical
TGF-beta signaling in T cells: roles in lymphoid and epithelial neoplasia.
PMID 16123803·Oncogene·2005
6-review
Smad-dependent cooperative regulation of interleukin 2 receptor alpha chain gene expression by T cell receptor and transforming growth factor-beta.
PMID 16087671·J Biol Chem·2005
7-preclinical
Disruption of the TGF-beta pathway and modeling human cancer in mice.
PMID 15935406·Mutat Res·2005
6-review
Cutting edge: p27Kip1 deficiency reduces the requirement for CD28-mediated costimulation in naive CD8+ but not CD4+ T lymphocytes.
PMID 15728451·J Immunol·2005
4-observational
CD28 disruption exacerbates inflammation in Tgf-beta1-/- mice: in vivo suppression by CD4+CD25+ regulatory T cells independent of autocrine TGF-beta1.
PMID 15016653·Blood·2004
7-preclinical
IL-13 activates a mechanism of tissue fibrosis that is completely TGF-beta independent.
PMID 15356151·J Immunol·2004
7-preclinical
p21Cip1 and p27Kip1 act in synergy to alter the sensitivity of naive T cells to TGF-beta-mediated G1 arrest through modulation of IL-2 responsiveness.
PMID 15322169·J Immunol·2004
7-preclinical
Depressed adrenomedullin in the embryonic transforming growth factor-beta1 null mouse becomes elevated postnatally.
PMID 15005577·Int J Dev Biol·2004
7-preclinical
Data courtesy of the U.S. National Library of Medicine (NLM). Ltrl is not affiliated with or endorsed by NLM.
Contact & Hours
- Address
- 11100 EUCLID AVE
CLEVELAND, OH 44106 - Phone
- (216) 844-7700
Quick Facts
- NPI
- 1467589739
- Entity Type
- Individual
- Gender
- Male
- Medicare
- Not confirmed
- Specialties
- 2
- Locations
- 1
- Publications
- 20
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