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ALBERT LA SPADA, MD
MD
Clinical Genetics (M.D.) Physician
NPI: 1487744330Individual
Specialties, Licenses & Credentials
Clinical Molecular Genetics Physician
Medical Genetics — Clinical Molecular Genetics
Code: 207SG0203X
G88598(CA)
Anatomic Pathology & Clinical Pathology Physician
Pathology — Anatomic Pathology & Clinical Pathology
Code: 207ZP0102X
G88598(CA)
Clinical Genetics (M.D.) PhysicianPrimary
Medical Genetics — Clinical Genetics (M.D.)
Code: 207SG0201X
G88598(CA)
Research & Publications (20)
Huntington's disease and neurogenesis: FGF-2 to the rescue?
PMID 16330780·Proc Natl Acad Sci U S A·2005
7-preclinical
Polyglutamine-expanded ataxin-7 antagonizes CRX function and induces cone-rod dystrophy in a mouse model of SCA7.
PMID 11580893·Neuron·2001
7-preclinical
Autophagy activation and enhanced mitophagy characterize the Purkinje cells of pcd mice prior to neuronal death.
PMID 19640278·Mol Brain·2009
7-preclinical
Polyglutamine-expanded androgen receptor truncation fragments activate a Bax-dependent apoptotic cascade mediated by DP5/Hrk.
PMID 19228953·J Neurosci·2009
7-preclinical
Development of selective nutrient deprivation as a system to study autophagy induction and regulation in neurons.
PMID 19363305·Autophagy·2009
7-preclinical
Getting a handle on Huntington's disease: silencing neurodegeneration.
PMID 19265826·Nat Med·2009
7-preclinical
Nutrient deprivation induces neuronal autophagy and implicates reduced insulin signaling in neuroprotective autophagy activation.
PMID 19017649·J Biol Chem·2009
7-preclinical
CTCF cis-regulates trinucleotide repeat instability in an epigenetic manner: a novel basis for mutational hot spot determination.
PMID 19008940·PLoS Genet·2008
7-preclinical
Molecular pathogenesis and cellular pathology of spinocerebellar ataxia type 7 neurodegeneration.
PMID 18418675·Cerebellum·2008
6-review
Spinocerebellar ataxia type 7 (SCA7): widespread brain damage in an adult-onset patient with progressive visual impairments in comparison with an adult-onset patient without visual impairments.
PMID 17971076·Neuropathol Appl Neurobiol·2008
5-case
The zinc-binding domain of Nna1 is required to prevent retinal photoreceptor loss and cerebellar ataxia in Purkinje cell degeneration (pcd) mice.
PMID 18602413·Vision Res·2008
7-preclinical
Androgen receptor function in motor neuron survival and degeneration.
PMID 18625411·Phys Med Rehabil Clin N Am·2008
6-review
Proteolytic cleavage of ataxin-7 by caspase-7 modulates cellular toxicity and transcriptional dysregulation.
PMID 17646170·J Biol Chem·2007
7-preclinical
Akt blocks ligand binding and protects against expanded polyglutamine androgen receptor toxicity.
PMID 17470458·Hum Mol Genet·2007
7-preclinical
Visceral neuropathy and intestinal pseudo-obstruction in a murine model of a nuclear inclusion disease.
PMID 18054568·Gastroenterology·2007
7-preclinical
Bergmann glia expression of polyglutamine-expanded ataxin-7 produces neurodegeneration by impairing glutamate transport.
PMID 16936724·Nat Neurosci·2006
4-observational
Beta-synuclein modulates alpha-synuclein neurotoxicity by reducing alpha-synuclein protein expression.
PMID 16959793·Hum Mol Genet·2006
7-preclinical
Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegeneration.
PMID 17055784·Cell Metab·2006
7-preclinical
Data courtesy of the U.S. National Library of Medicine (NLM). Ltrl is not affiliated with or endorsed by NLM.
Contact & Hours
Via practice · 2 locations total
- Address
- 200 S MANCHESTER AVE STE 110
ORANGE, CA 92868 - Phone
- (714) 456-2332
Quick Facts
- NPI
- 1487744330
- Entity Type
- Individual
- Gender
- Male
- Medicare
- Not confirmed
- Specialties
- 3
- Locations
- 2
- Publications
- 20
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