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GEORGE SEMPLE, DO
DO
Family Medicine Physician
NPI: 1578571345IndividualAccepts Medicare
Specialties, Licenses & Credentials
Family Medicine PhysicianPrimary
Family Medicine
Code: 207Q00000X
DO-548(AL)
CMS Specialties
PrimaryFAMILY PRACTICE
Education
PHILADELPHIA COLLEGE OF OSTEOPATHIC MEDICINE
Class of 1996
Research & Publications (20)
3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydro-cyclopentapyrazole (MK-0354): a partial agonist of the nicotinic acid receptor, G-protein coupled receptor 109a, with antilipolytic but no vasodilatory activity in mice.
PMID 18665582·J Med Chem·2008
7-preclinical
Discovery of the first potent and orally efficacious agonist of the orphan G-protein coupled receptor 119.
PMID 18698756·J Med Chem·2008
7-preclinical
Recent progress in the discovery of niacin receptor agonists.
PMID 17659487·Curr Opin Drug Discov Devel·2007
6-review
Nicotinic acid receptor agonists differentially activate downstream effectors.
PMID 17452318·J Biol Chem·2007
7-preclinical
5-N,N-Disubstituted 5-aminopyrazole-3-carboxylic acids are highly potent agonists of GPR109b.
PMID 19524438·Bioorg Med Chem Lett·2009
7-preclinical
Solubilized phenyl-pyrazole ureas as potent, selective 5-HT(2A) inverse-agonists and their application as antiplatelet agents.
PMID 19665894·Bioorg Med Chem Lett·2009
8-other
New benzylureas as a novel series of potent, nonpeptidic vasopressin V2 receptor agonists.
PMID 19053774·J Med Chem·2008
7-preclinical
Novel H3 receptor antagonists with improved pharmacokinetic profiles.
PMID 18554904·Bioorg Med Chem Lett·2008
7-preclinical
A new family of H3 receptor antagonists based on the natural product Conessine.
PMID 18194865·Bioorg Med Chem Lett·2008
7-preclinical
Analogues of acifran: agonists of the high and low affinity niacin receptors, GPR109a and GPR109b.
PMID 17358052·J Med Chem·2007
8-other
3-Nitro-4-amino benzoic acids and 6-amino nicotinic acids are highly selective agonists of GPR109b.
PMID 17931863·Bioorg Med Chem Lett·2007
4-observational
Fluorinated pyrazole acids are agonists of the high affinity niacin receptor GPR109a.
PMID 17804224·Bioorg Med Chem Lett·2007
7-preclinical
Agonist lead identification for the high affinity niacin receptor GPR109a.
PMID 17588745·Bioorg Med Chem Lett·2007
7-preclinical
A role for beta-cell-expressed G protein-coupled receptor 119 in glycemic control by enhancing glucose-dependent insulin release.
PMID 17289847·Endocrinology·2007
7-preclinical
Identification of 4-amino-2-cyclohexylaminoquinazolines as metabolically stable melanin-concentrating hormone receptor 1 antagonists.
PMID 16434202·Bioorg Med Chem·2006
7-preclinical
1-Alkyl-benzotriazole-5-carboxylic acids are highly selective agonists of the human orphan G-protein-coupled receptor GPR109b.
PMID 16480258·J Med Chem·2006
8-other
Discovery of 4-(dimethylamino)quinazolines as potent and selective antagonists for the melanin-concentrating hormone receptor 1.
PMID 15863317·Bioorg Med Chem Lett·2005
8-other
Anxiolytic- and antidepressant-like profile of ATC0065 and ATC0175: nonpeptidic and orally active melanin-concentrating hormone receptor 1 antagonists.
PMID 15677346·J Pharmacol Exp Ther·2005
4-observational
ATC0175: an orally active melanin-concentrating hormone receptor 1 antagonist for the potential treatment of depression and anxiety.
PMID 16614734·CNS Drug Rev·2005
6-review
Data courtesy of the U.S. National Library of Medicine (NLM). Ltrl is not affiliated with or endorsed by NLM.
Contact & Hours
- Address
- FAMILY CARE CLINIC, NAVAL HOSPITAL
CHERRY POINT, NC 28533 - Phone
- (252) 466-0230
Quick Facts
- NPI
- 1578571345
- Entity Type
- Individual
- Gender
- Male
- Medicare
- Accepted
- Specialties
- 1
- Locations
- 1
- Years in Practice
- 30
- Publications
- 20
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