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TIMOTHY CIHLAR, PHARMD
PHARMD
Pharmacist
NPI: 1588035281Individual
Specialties, Licenses & Credentials
PharmacistPrimary
Pharmacist
Code: 183500000X
PHA.0020842(CO)
Research & Publications (20)
Novel nucleotide human immunodeficiency virus reverse transcriptase inhibitor GS-9148 with a low nephrotoxic potential: characterization of renal transport and accumulation.
PMID 19001108·Antimicrob Agents Chemother·2009
7-preclinical
Design and profiling of GS-9148, a novel nucleotide analog active against nucleoside-resistant variants of human immunodeficiency virus type 1, and its orally bioavailable phosphonoamidate prodrug, GS-9131.
PMID 18056282·Antimicrob Agents Chemother·2008
7-preclinical
Molecular assessment of the potential for renal drug interactions between tenofovir and HIV protease inhibitors.
PMID 17503669·Antivir Ther·2007
7-preclinical
Nucleotide HIV reverse transcriptase inhibitors: tenofovir and beyond.
PMID 19372836·Curr Opin HIV AIDS·2006
8-other
Tenofovir exhibits low cytotoxicity in various human cell types: comparison with other nucleoside reverse transcriptase inhibitors.
PMID 11888656·Antiviral Res·2002
4-observational
Fluorescence-based assay for the interaction of small molecules with the human renal organic anion transporter 1.
PMID 10929807·Anal Biochem·2000
7-preclinical
Design, synthesis, and anti-HIV activity of 4'-modified carbocyclic nucleoside phosphonate reverse transcriptase inhibitors.
PMID 19179082·Bioorg Med Chem·2009
8-other
Intracellular metabolism of the nucleotide prodrug GS-9131, a potent anti-human immunodeficiency virus agent.
PMID 18056281·Antimicrob Agents Chemother·2008
8-other
Chronic administration of tenofovir to rhesus macaques from infancy through adulthood and pregnancy: summary of pharmacokinetics and biological and virological effects.
PMID 18573931·Antimicrob Agents Chemother·2008
7-preclinical
GS-9219--a novel acyclic nucleotide analogue with potent antineoplastic activity in dogs with spontaneous non-Hodgkin's lymphoma.
PMID 18451250·Clin Cancer Res·2008
7-preclinical
Activation of 9-[(R)-2-[[(S)-[[(S)-1-(Isopropoxycarbonyl)ethyl]amino] phenoxyphosphinyl]-methoxy]propyl]adenine (GS-7340) and other tenofovir phosphonoamidate prodrugs by human proteases.
PMID 18430788·Mol Pharmacol·2008
8-other
Synthesis and anti-HIV activity of GS-9148 (2'-Fd4AP), a novel nucleoside phosphonate HIV reverse transcriptase inhibitor.
PMID 18164198·Bioorg Med Chem Lett·2008
8-other
Synthesis and anti-HIV activity of 2'-fluorine modified nucleoside phosphonates: analogs of GS-9148.
PMID 18082402·Bioorg Med Chem Lett·2008
8-other
Synthesis, anti-HIV activity, and resistance profile of thymidine phosphonomethoxy nucleosides and their bis-isopropyloxymethylcarbonyl (bisPOC) prodrugs.
PMID 17562366·Bioorg Med Chem·2007
8-other
Synthesis and anti-HIV activity of cyclic pyrimidine phosphonomethoxy nucleosides and their prodrugs: a comparison of phosphonates and corresponding nucleosides.
PMID 18066858·Nucleosides Nucleotides Nucleic Acids·2007
4-observational
Synthesis, anti-HIV activity, and resistance profiles of ribose modified nucleoside phosphonates.
PMID 18029175·Bioorg Med Chem Lett·2007
8-other
Unlikely association of multidrug-resistance protein 2 single-nucleotide polymorphisms with tenofovir-induced renal adverse events.
PMID 17397012·J Infect Dis·2007
8-other
Cathepsin A is the major hydrolase catalyzing the intracellular hydrolysis of the antiretroviral nucleotide phosphonoamidate prodrugs GS-7340 and GS-9131.
PMID 17145787·Antimicrob Agents Chemother·2007
8-other
Mechanism of active renal tubular efflux of tenofovir.
PMID 17005808·Antimicrob Agents Chemother·2006
7-preclinical
Data courtesy of the U.S. National Library of Medicine (NLM). Ltrl is not affiliated with or endorsed by NLM.
Contact & Hours
- Address
- 1620 FILLMORE ST APT 313
DENVER, CO 80206 - Phone
- (303) 520-9332
Quick Facts
- NPI
- 1588035281
- Entity Type
- Individual
- Gender
- Male
- Medicare
- Not confirmed
- Specialties
- 1
- Locations
- 1
- Publications
- 20
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