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GRETCHEN DOSS, PHARMD
PHARMD
Pharmacist
NPI: 1588976765Individual
Specialties, Licenses & Credentials
PharmacistPrimary
Pharmacist
Code: 183500000X
0000033846(TN)0202207925(VA)
Research & Publications (20)
Potent, brain-penetrant, hydroisoindoline-based human neurokinin-1 receptor antagonists.
PMID 19354254·J Med Chem·2009
7-preclinical
Metabolism and renal elimination of gaboxadol in humans: role of UDP-glucuronosyltransferases and transporters.
PMID 19082692·Pharm Res·2009
7-preclinical
Conformational studies of 3-amino-1-alkyl-cyclopentane carboxamide CCR2 antagonists leading to new spirocyclic antagonists.
PMID 18215519·Bioorg Med Chem Lett·2008
8-other
Fused bicyclic pyrrolizinones as new scaffolds for human NK1 antagonists.
PMID 18248994·Bioorg Med Chem·2008
8-other
Conformational analysis and receptor docking of N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (taranabant, MK-0364), a novel, acyclic cannabinoid-1 receptor inverse agonist.
PMID 18333607·J Med Chem·2008
7-preclinical
Characterization of 1'-hydroxymidazolam glucuronidation in human liver microsomes.
PMID 17998299·Drug Metab Dispos·2008
7-preclinical
Computational and structural investigation of deleterious functional SNPs in breast cancer BRCA2 gene.
PMID 18724707·Sheng Wu Gong Cheng Xue Bao·2008
8-other
In vitro metabolic activation of lumiracoxib in rat and human liver preparations.
PMID 17998295·Drug Metab Dispos·2008
7-preclinical
Absorption, metabolism, and excretion of [(14)C]MK-0524, a prostaglandin D(2) receptor antagonist, in humans.
PMID 17431030·Drug Metab Dispos·2007
3-trial
Rational design of a novel, potent, and orally bioavailable cyclohexylamine DPP-4 inhibitor by application of molecular modeling and X-ray crystallography of sitagliptin.
PMID 17433672·Bioorg Med Chem Lett·2007
8-other
Species differences in metabolism and pharmacokinetics of a sphingosine-1-phosphate receptor agonist in rats and dogs: formation of a unique glutathione adduct in the rat.
PMID 16698892·Drug Metab Dispos·2006
4-observational
Addressing metabolic activation as an integral component of drug design.
PMID 17145693·Drug Metab Rev·2006
6-review
Evidence for the bioactivation of zomepirac and tolmetin by an oxidative pathway: identification of glutathione adducts in vitro in human liver microsomes and in vivo in rats.
PMID 16251255·Drug Metab Dispos·2006
7-preclinical
Synthesis of functionalized 1,8-naphthyridinones and their evaluation as novel, orally active CB1 receptor inverse agonists.
PMID 16263284·Bioorg Med Chem Lett·2006
7-preclinical
In vitro bioactivation of dihydrobenzoxathiin selective estrogen receptor modulators by cytochrome P450 3A4 in human liver microsomes: formation of reactive iminium and quinone type metabolites.
PMID 15833027·Chem Res Toxicol·2005
8-other
Dipeptidyl peptidase IV inhibitors derived from beta-aminoacylpiperidines bearing a fused thiazole, oxazole, isoxazole, or pyrazole.
PMID 15837304·Bioorg Med Chem Lett·2005
8-other
Zafirlukast metabolism by cytochrome P450 3A4 produces an electrophilic alpha,beta-unsaturated iminium species that results in the selective mechanism-based inactivation of the enzyme.
PMID 16167835·Chem Res Toxicol·2005
7-preclinical
Metabolic activation of a pentafluorophenylethylamine derivative: formation of glutathione conjugates in vitro in the rat.
PMID 16316929·Xenobiotica·2005
7-preclinical
Data courtesy of the U.S. National Library of Medicine (NLM). Ltrl is not affiliated with or endorsed by NLM.
Contact & Hours
- Address
- 2200 MEMORIAL BLVD
KINGSPORT, TN 37664 - Phone
- (423) 246-0234
Quick Facts
- NPI
- 1588976765
- Entity Type
- Individual
- Gender
- Female
- Medicare
- Not confirmed
- Specialties
- 2
- Locations
- 1
- Publications
- 20
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