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JOHN WRIGLEY, M.D
M.D
Urology Physician
NPI: 1629088471Individual
Specialties, Licenses & Credentials
Urology PhysicianPrimary
Urology
Code: 208800000X
MD0993(OR)
Research & Publications (20)
Functional overexpression of gamma-secretase reveals protease-independent trafficking functions and a critical role of lipids for protease activity.
PMID 15613471·J Biol Chem·2005
8-other
Conserved residues within the putative active site of gamma-secretase differentially influence enzyme activity and inhibitor binding.
PMID 15341515·J Neurochem·2004
4-observational
Novel orally bioavailable gamma-secretase inhibitors with excellent in vivo activity.
PMID 19432431·J Med Chem·2009
7-preclinical
Intra- or intercomplex binding to the gamma-secretase enzyme. A model to differentiate inhibitor classes.
PMID 16899457·J Biol Chem·2006
8-other
3-Substituted gem-cyclohexane sulfone based gamma-secretase inhibitors for Alzheimer's disease: conformational analysis and biological activity.
PMID 16682202·Bioorg Med Chem Lett·2006
8-other
3,4-Fused cyclohexyl sulfones as gamma-secretase inhibitors.
PMID 16617016·Bioorg Med Chem Lett·2006
7-preclinical
Resistance to a triple combination of broad-spectrum anthelmintics in naturally-acquired Ostertagia circumcincta infections in sheep.
PMID 16528395·N Z Vet J·2006
7-preclinical
The geminal dimethyl analogue of Flurbiprofen as a novel Abeta42 inhibitor and potential Alzheimer's disease modifying agent.
PMID 16455248·Bioorg Med Chem Lett·2006
7-preclinical
4-substituted cyclohexyl sulfones as potent, orally active gamma-secretase inhibitors.
PMID 16275079·Bioorg Med Chem Lett·2006
7-preclinical
Methionine-rich repeat proteins: a family of membrane-associated proteins which contain unusual repeat regions.
PMID 15737327·Biochim Biophys Acta·2005
7-preclinical
Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site. Evidence for an allosteric mechanism.
PMID 15304503·J Biol Chem·2004
8-other
High affinity, bioavailable 3-amino-1,4-benzodiazepine-based gamma-secretase inhibitors.
PMID 14592525·Bioorg Med Chem Lett·2003
8-other
In vitro characterization of the presenilin-dependent gamma-secretase complex using a novel affinity ligand.
PMID 12846562·Biochemistry·2003
8-other
Design and synthesis of highly potent benzodiazepine gamma-secretase inhibitors: preparation of (2S,3R)-3-(3,4-difluorophenyl)-2-(4-fluorophenyl)-4- hydroxy-N-((3S)-1-methyl-2-oxo-5- phenyl-2,3-dihydro-1H-benzo[e][1,4]-diazepin-3-yl)butyramide by use of an asymmetric Ireland-Claisen rearrangement.
PMID 12773031·J Med Chem·2003
8-other
A new series of potent benzodiazepine gamma-secretase inhibitors.
PMID 12482419·Bioorg Med Chem Lett·2003
8-other
Topological analysis of peripherin/rds and abnormal glycosylation of the pathogenic Pro216-->Leu mutation.
PMID 12207562·Biochem J·2002
7-preclinical
Generation of C-terminally truncated amyloid-beta peptides is dependent on gamma-secretase activity.
PMID 12153480·J Neurochem·2002
8-other
Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology.
PMID 11574530·J Biol Chem·2001
7-preclinical
Improved vascular endothelial function after oral B vitamins: An effect mediated through reduced concentrations of free plasma homocysteine.
PMID 11076820·Circulation·2000
3-trial
Data courtesy of the U.S. National Library of Medicine (NLM). Ltrl is not affiliated with or endorsed by NLM.
Contact & Hours
- Address
- 1813 W HARVARD AVE, SUITE 214
ROSEBURG, OR 97470 - Phone
- (541) 672-0091
Quick Facts
- NPI
- 1629088471
- Entity Type
- Individual
- Gender
- Female
- Medicare
- Not confirmed
- Specialties
- 1
- Locations
- 1
- Publications
- 20
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