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MATTHEW SHEARMAN, PHARMD
PHARMD
Pharmacist
NPI: 1629553862Individual
Specialties, Licenses & Credentials
PharmacistPrimary
Pharmacist
Code: 183500000X
RP452783(PA)
Research & Publications (20)
L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity.
PMID 10913280·Biochemistry·2000
7-preclinical
Novel orally bioavailable gamma-secretase inhibitors with excellent in vivo activity.
PMID 19432431·J Med Chem·2009
7-preclinical
Fenton chemistry and oxidative stress mediate the toxicity of the beta-amyloid peptide in a Drosophila model of Alzheimer's disease.
PMID 19519625·Eur J Neurosci·2009
7-preclinical
Sulfonamide derivatives of bridgehead substituted bicyclo[4.2.1]nonanes as gamma-secretase inhibitors.
PMID 18061448·Bioorg Med Chem Lett·2008
7-preclinical
The novel gamma secretase inhibitor N-[cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide (MRK-560) reduces amyloid plaque deposition without evidence of notch-related pathology in the Tg2576 mouse.
PMID 17099072·J Pharmacol Exp Ther·2007
7-preclinical
Apoptosis in T cell acute lymphoblastic leukemia cells after cell cycle arrest induced by pharmacological inhibition of notch signaling.
PMID 17317574·Chem Biol·2007
8-other
Beyond amyloid: the next generation of Alzheimer's disease therapeutics.
PMID 17932415·Mol Interv·2007
6-review
The geminal dimethyl analogue of Flurbiprofen as a novel Abeta42 inhibitor and potential Alzheimer's disease modifying agent.
PMID 16455248·Bioorg Med Chem Lett·2006
7-preclinical
Quantification of Alzheimer pathology in ageing and dementia: age-related accumulation of amyloid-beta(42) peptide in vascular dementia.
PMID 16599940·Neuropathol Appl Neurobiol·2006
4-observational
3,4-Fused cyclohexyl sulfones as gamma-secretase inhibitors.
PMID 16617016·Bioorg Med Chem Lett·2006
7-preclinical
3-Substituted gem-cyclohexane sulfone based gamma-secretase inhibitors for Alzheimer's disease: conformational analysis and biological activity.
PMID 16682202·Bioorg Med Chem Lett·2006
8-other
A comparative assessment of gamma-secretase activity in transgenic and non-transgenic rodent brain.
PMID 16859750·J Neurosci Methods·2006
4-observational
Intra- or intercomplex binding to the gamma-secretase enzyme. A model to differentiate inhibitor classes.
PMID 16899457·J Biol Chem·2006
8-other
In vivo characterization of Abeta(40) changes in brain and cerebrospinal fluid using the novel gamma-secretase inhibitor N-[cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide (MRK-560) in the rat.
PMID 16443723·J Pharmacol Exp Ther·2006
7-preclinical
4-substituted cyclohexyl sulfones as potent, orally active gamma-secretase inhibitors.
PMID 16275079·Bioorg Med Chem Lett·2006
7-preclinical
LRRTM3 promotes processing of amyloid-precursor protein by BACE1 and is a positional candidate gene for late-onset Alzheimer's disease.
PMID 17098871·Proc Natl Acad Sci U S A·2006
7-preclinical
C-terminal PAL motif of presenilin and presenilin homologues required for normal active site conformation.
PMID 16305624·J Neurochem·2006
8-other
Aryl sulfones: a new class of gamma-secretase inhibitors.
PMID 15863342·Bioorg Med Chem Lett·2005
8-other
Two domains within the first putative transmembrane domain of presenilin 1 differentially influence presenilinase and gamma-secretase activity.
PMID 16001967·J Neurochem·2005
7-preclinical
Data courtesy of the U.S. National Library of Medicine (NLM). Ltrl is not affiliated with or endorsed by NLM.
Contact & Hours
- Address
- 1395 E BOOT RD
WEST CHESTER, PA 19380 - Phone
- (610) 738-8870
Quick Facts
- NPI
- 1629553862
- Entity Type
- Individual
- Gender
- Male
- Medicare
- Not confirmed
- Specialties
- 1
- Locations
- 1
- Publications
- 20
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