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BRADLEY DENKER, MD
MD
Nephrology Physician
NPI: 1669438727IndividualAccepts Medicare
Specialties, Licenses & Credentials
Nephrology PhysicianPrimary
Internal Medicine — Nephrology
Code: 207RN0300X
59106(MA)
CMS Specialties
PrimaryNEPHROLOGY
Education
STATE UNIVERSITY OF NY UPSTATE MEDICAL UNIVERSITY
Class of 1984
Research & Publications (19)
Heterotrimeric G proteins and apoptosis: intersecting signaling pathways leading to context dependent phenotypes.
PMID 19601805·Curr Mol Med·2009
6-review
Galpha12 regulates protein interactions within the MDCK cell tight junction and inhibits tight-junction assembly.
PMID 18285450·J Cell Sci·2008
7-preclinical
Functional genetic variation in aminopeptidase A (ENPEP): lack of clear association with focal and segmental glomerulosclerosis (FSGS).
PMID 18206321·Gene·2008
8-other
Disease-associated mutant alpha-actinin-4 reveals a mechanism for regulating its F-actin-binding affinity.
PMID 17901210·Proc Natl Acad Sci U S A·2007
7-preclinical
Galpha12 stimulates apoptosis in epithelial cells through JNK1-mediated Bcl-2 degradation and up-regulation of IkappaBalpha.
PMID 17565996·J Biol Chem·2007
7-preclinical
Domains necessary for Galpha12 binding and stimulation of protein phosphatase-2A (PP2A): Is Galpha12 a novel regulatory subunit of PP2A?
PMID 17303700·Mol Pharmacol·2007
7-preclinical
Cell-cell interactions in the kidney: inducible expression of mutant G protein alpha-subunits in Madin-Darby canine kidney cells for studies of epithelial cell junction structure and function.
PMID 16799189·Methods Mol Biol·2006
4-observational
Cultured podocytes establish a size-selective barrier regulated by specific signaling pathways and demonstrate synchronized barrier assembly in a calcium switch model of junction formation.
PMID 15843471·J Am Soc Nephrol·2005
7-preclinical
Purkinje cell protein-2 (Pcp2) stimulates differentiation in PC12 cells by Gbetagamma-mediated activation of Ras and p38 MAPK.
PMID 15948714·Biochem J·2005
7-preclinical
Galpha12 directly interacts with PP2A: evidence FOR Galpha12-stimulated PP2A phosphatase activity and dephosphorylation of microtubule-associated protein, tau.
PMID 15525651·J Biol Chem·2004
7-preclinical
Alpha-actinin-4-mediated FSGS: an inherited kidney disease caused by an aggregated and rapidly degraded cytoskeletal protein.
PMID 15208719·PLoS Biol·2004
7-preclinical
Galpha12 regulates epithelial cell junctions through Src tyrosine kinases.
PMID 12890651·Am J Physiol Cell Physiol·2003
7-preclinical
Zonula occludens-1 is a scaffolding protein for signaling molecules. Galpha(12) directly binds to the Src homology 3 domain and regulates paracellular permeability in epithelial cells.
PMID 12023272·J Biol Chem·2002
7-preclinical
Association and colocalization of G protein alpha subunits and Purkinje cell protein 2 (Pcp2) in mammalian cerebellum.
PMID 12424730·J Neurosci Res·2002
7-preclinical
Expanding role of G proteins in tight junction regulation: Galpha(s) stimulates TJ assembly.
PMID 11444833·Biochem Biophys Res Commun·2001
7-preclinical
Reassembly of the tight junction after oxidative stress depends on tyrosine kinase activity.
PMID 11294856·J Biol Chem·2001
7-preclinical
Degradation of heterotrimeric Galpha(o) subunits via the proteosome pathway is induced by the hsp90-specific compound geldanamycin.
PMID 10636845·J Biol Chem·2000
4-observational
Diode-Pumped Er-Yb:Glass Laser Passively Q Switched by Use of Co(2+):MgAl(2)O(4) as a Saturable Absorber.
PMID 18354626·Appl Opt·2000
8-other
Data courtesy of the U.S. National Library of Medicine (NLM). Ltrl is not affiliated with or endorsed by NLM.
Contact & Hours
- Address
- 133 BROOKLINE AVE
BOSTON, MA 02215 - Phone
- (617) 421-1126
Quick Facts
- NPI
- 1669438727
- Entity Type
- Individual
- Gender
- Male
- Medicare
- Accepted
- Specialties
- 1
- Locations
- 1
- Years in Practice
- 42
- Publications
- 19
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