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DAVID SEGALOFF, MD
MD
Pediatrics Physician
NPI: 1669473666Individual
Specialties, Licenses & Credentials
Pediatrics PhysicianPrimary
Pediatrics
Code: 208000000X
4301054871(MI)
Research & Publications (20)
Bioluminescence resonance energy transfer studies reveal constitutive dimerization of the human lutropin receptor and a lack of correlation between receptor activation and the propensity for dimerization.
PMID 19147490·J Biol Chem·2009
8-other
A cell surface inactive mutant of the human lutropin receptor (hLHR) attenuates signaling of wild-type or constitutively active receptors via heterodimerization.
PMID 19616090·Cell Signal·2009
8-other
An intracellular loop (IL2) residue confers different basal constitutive activities to the human lutropin receptor and human thyrotropin receptor through structural communication between IL2 and helix 6, via helix 3.
PMID 18162522·Endocrinology·2008
8-other
Insights learned from L457(3.43)R, an activating mutant of the human lutropin receptor.
PMID 17055147·Mol Cell Endocrinol·2007
6-review
Evaluating the roles of follicle-stimulating hormone receptor polymorphisms in gonadal hyperstimulation associated with severe juvenile primary hypothyroidism.
PMID 17356048·J Clin Endocrinol Metab·2007
8-other
Intrinsic differences in the response of the human lutropin receptor versus the human follitropin receptor to activating mutations.
PMID 17609213·J Biol Chem·2007
4-observational
Molecular analysis of the neuropeptide Y1 receptor gene in human idiopathic gonadotropin-dependent precocious puberty and isolated hypogonadotropic hypogonadism.
PMID 17140570·Fertil Steril·2007
8-other
Functional analyses of melanocortin-4 receptor mutations identified from patients with binge eating disorder and nonobese or obese subjects.
PMID 16030156·J Clin Endocrinol Metab·2005
8-other
The formation of a salt bridge between helices 3 and 6 is responsible for the constitutive activity and lack of hormone responsiveness of the naturally occurring L457R mutation of the human lutropin receptor.
PMID 15908694·J Biol Chem·2005
8-other
Constitutive and agonist-dependent self-association of the cell surface human lutropin receptor.
PMID 14594799·J Biol Chem·2004
8-other
Functional characterization of melanocortin-3 receptor variants identify a loss-of-function mutation involving an amino acid critical for G protein-coupled receptor activation.
PMID 15292330·J Clin Endocrinol Metab·2004
8-other
Intracellularly located misfolded glycoprotein hormone receptors associate with different chaperone proteins than their cognate wild-type receptors.
PMID 15105436·Mol Endocrinol·2004
8-other
Desensitization of Gs-coupled receptor signaling by constitutively active mutants of the human lutropin/choriogonadotropin receptor.
PMID 12629106·J Clin Endocrinol Metab·2003
8-other
Functional characterization of melanocortin-4 receptor mutations associated with childhood obesity.
PMID 12959994·Endocrinology·2003
8-other
Deletion of codons 88-92 of the melanocortin-4 receptor gene: a novel deleterious mutation in an obese female.
PMID 14671178·J Clin Endocrinol Metab·2003
5-case
N-linked carbohydrates on G protein-coupled receptors: mapping sites of attachment and determining functional roles.
PMID 11665568·Methods Enzymol·2002
8-other
Constitutive activation of the LH receptor is associated with an alteration in the conformation of the ectodomain.
PMID 12242044·Mol Cell Endocrinol·2002
8-other
Data courtesy of the U.S. National Library of Medicine (NLM). Ltrl is not affiliated with or endorsed by NLM.
Contact & Hours
- Address
- 26850 PROVIDENCE PKWY, SUITE 455
NOVI, MI 48374 - Phone
- (248) 465-4847
Quick Facts
- NPI
- 1669473666
- Entity Type
- Individual
- Gender
- Male
- Medicare
- Not confirmed
- Specialties
- 1
- Locations
- 1
- Publications
- 20
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