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TAMARA ANGELES, PHARMD
PHARMD
Pharmacist
NPI: 1679925994Individual
Specialties, Licenses & Credentials
PharmacistPrimary
Pharmacist
Code: 183500000X
19070(NV)
Research & Publications (20)
ALK mutants in the kinase domain exhibit altered kinase activity and differential sensitivity to small molecule ALK inhibitors.
PMID 19249873·Biochemistry·2009
7-preclinical
Mixed-lineage kinase 1 and mixed-lineage kinase 3 subtype-selective dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: optimization, mixed-lineage kinase 1 crystallography, and oral in vivo activity in 1-methyl-4-phenyltetrahydropyridine models.
PMID 18714982·J Med Chem·2008
7-preclinical
TrkA kinase inhibitors from a library of modified and isosteric Staurosporine aglycone.
PMID 18508265·Bioorg Med Chem Lett·2008
7-preclinical
TIE-2/VEGF-R2 SAR and in vitro activity of C3-acyl dihydroindazolo[5,4-a]pyrrolo[3,4-c]carbazole analogs.
PMID 18343109·Bioorg Med Chem Lett·2008
7-preclinical
Design and synthesis of dihydroindazolo[5,4-a]pyrrolo[3,4-c]carbazole oximes as potent dual inhibitors of TIE-2 and VEGF-R2 receptor tyrosine kinases.
PMID 18308565·Bioorg Med Chem Lett·2008
7-preclinical
Lestaurtinib (CEP701) is a JAK2 inhibitor that suppresses JAK2/STAT5 signaling and the proliferation of primary erythroid cells from patients with myeloproliferative disorders.
PMID 17984313·Blood·2008
7-preclinical
Synthesis and mixed lineage kinase activity of pyrrolocarbazole and isoindolone analogs of (+)K-252a.
PMID 17266195·J Med Chem·2007
7-preclinical
1,2,3-Thiadiazole substituted pyrazolones as potent KDR/VEGFR-2 kinase inhibitors.
PMID 17239587·Bioorg Med Chem Lett·2007
7-preclinical
Novel C-3 N-urea, amide, and carbamate dihydroindazolo[5,4-a]pyrrolo[3,4-c]carbazole analogs as potent TIE-2 and VEGF-R2 dual inhibitors.
PMID 16890434·Bioorg Med Chem Lett·2006
7-preclinical
Structure-guided identification of novel VEGFR-2 kinase inhibitors via solution phase parallel synthesis.
PMID 16460933·Bioorg Med Chem Lett·2006
7-preclinical
Anaplastic lymphoma kinase activity is essential for the proliferation and survival of anaplastic large-cell lymphoma cells.
PMID 16254137·Blood·2006
8-other
Synthesis, modeling, and in vitro activity of (3'S)-epi-K-252a analogues. Elucidating the stereochemical requirements of the 3'-sugar alcohol on trkA tyrosine kinase activity.
PMID 15916429·J Med Chem·2005
7-preclinical
Phosphoregulation of mixed-lineage kinase 1 activity by multiple phosphorylation in the activation loop.
PMID 15610029·Biochemistry·2004
7-preclinical
A new class of potent vascular endothelial growth factor receptor tyrosine kinase inhibitors: structure-activity relationships for a series of 9-alkoxymethyl-12-(3-hydroxypropyl)indeno[2,1-a]pyrrolo[3,4-c]carbazole-5-ones and the identification of CEP-5214 and its dimethylglycine ester prodrug clinical candidate CEP-7055.
PMID 14640546·J Med Chem·2003
7-preclinical
CEP-7055: a novel, orally active pan inhibitor of vascular endothelial growth factor receptor tyrosine kinases with potent antiangiogenic activity and antitumor efficacy in preclinical models.
PMID 14522925·Cancer Res·2003
7-preclinical
The chemopreventive agent oltipraz possesses potent antiangiogenic activity in vitro, ex vivo, and in vivo and inhibits tumor xenograft growth.
PMID 11801568·Clin Cancer Res·2002
7-preclinical
Mixed lineage kinase activity of indolocarbazole analogues.
PMID 11755341·Bioorg Med Chem Lett·2002
7-preclinical
Cep-1347 (KT7515), a semisynthetic inhibitor of the mixed lineage kinase family.
PMID 11325962·J Biol Chem·2001
7-preclinical
Quantitative, high-throughput cell-based assays for inhibitors of trkA receptor.
PMID 10660449·Anal Biochem·2000
7-preclinical
Data courtesy of the U.S. National Library of Medicine (NLM). Ltrl is not affiliated with or endorsed by NLM.
Contact & Hours
- Address
- 2970 SAINT ROSE PKWY STE 120
HENDERSON, NV 89052 - Phone
- (702) 832-3320
Quick Facts
- NPI
- 1679925994
- Entity Type
- Individual
- Gender
- Female
- Medicare
- Not confirmed
- Specialties
- 1
- Locations
- 1
- Publications
- 20
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