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FRANK PERRINO, MD
MD
Internal Medicine Physician
NPI: 1700851805Individual
Specialties, Licenses & Credentials
Internal Medicine PhysicianPrimary
Internal Medicine
Code: 207R00000X
ME64885(FL)
Sleep Medicine (Internal Medicine) Physician
Internal Medicine — Sleep Medicine
Code: 207RS0012X
ME64885(FL)
Research & Publications (20)
DNA binding induces active site conformational change in the human TREX2 3'-exonuclease.
PMID 19321497·Nucleic Acids Res·2009
8-other
A DNA polymerase-{alpha}{middle dot}primase cofactor with homology to replication protein A-32 regulates DNA replication in mammalian cells.
PMID 19119139·J Biol Chem·2009
7-preclinical
RNaseH2 mutants that cause Aicardi-Goutieres syndrome are active nucleases.
PMID 19034401·J Mol Med (Berl)·2009
8-other
The TREX1 double-stranded DNA degradation activity is defective in dominant mutations associated with autoimmune disease.
PMID 18805785·J Biol Chem·2008
8-other
Cooperative DNA binding and communication across the dimer interface in the TREX2 3' --> 5'-exonuclease.
PMID 18534978·J Biol Chem·2008
8-other
Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus.
PMID 17660818·Nat Genet·2007
8-other
A mutation in TREX1 that impairs susceptibility to granzyme A-mediated cell death underlies familial chilblain lupus.
PMID 17440703·J Mol Med (Berl)·2007
7-preclinical
Heterozygous mutations in TREX1 cause familial chilblain lupus and dominant Aicardi-Goutieres syndrome.
PMID 17357087·Am J Hum Genet·2007
8-other
The crystal structure of TREX1 explains the 3' nucleotide specificity and reveals a polyproline II helix for protein partnering.
PMID 17293595·J Biol Chem·2007
7-preclinical
WRN exonuclease activity is blocked by DNA termini harboring 3' obstructive groups.
PMID 17224176·Mech Ageing Dev·2007
8-other
Structure of the Escherichia coli DNA polymerase III epsilon-HOT proofreading complex.
PMID 16973612·J Biol Chem·2006
8-other
Replication of N2-ethyldeoxyguanosine DNA adducts in the human embryonic kidney cell line 293.
PMID 16841965·Chem Res Toxicol·2006
4-observational
The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death.
PMID 16818237·Mol Cell·2006
8-other
Mutagenesis by exocyclic alkylamino purine adducts in Escherichia coli.
PMID 16488449·Mutat Res·2006
8-other
Polymerization past the N2-isopropylguanine and the N6-isopropyladenine DNA lesions with the translesion synthesis DNA polymerases eta and iota and the replicative DNA polymerase alpha.
PMID 16167838·Chem Res Toxicol·2005
8-other
The human TREX2 3' -> 5'-exonuclease structure suggests a mechanism for efficient nonprocessive DNA catalysis.
PMID 15661738·J Biol Chem·2005
8-other
Sequence variants in the 3'-->5' deoxyribonuclease TREX2: identification in a genetic screen and effects on catalysis by the recombinant proteins.
PMID 15581481·Adv Enzyme Regul·2004
4-observational
Dysfunctional proofreading in the Escherichia coli DNA polymerase III core.
PMID 15352874·Biochem J·2004
8-other
Data courtesy of the U.S. National Library of Medicine (NLM). Ltrl is not affiliated with or endorsed by NLM.
Contact & Hours
- Address
- 6301 MEMORIAL HWY, STE 204
TAMPA, FL 33615 - Phone
- (813) 884-2825
Quick Facts
- NPI
- 1700851805
- Entity Type
- Individual
- Gender
- Male
- Medicare
- Not confirmed
- Specialties
- 2
- Locations
- 1
- Publications
- 20
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