Back to Search
JONATHAN SCHARFSTEIN, MD
MD
Cardiovascular Disease Physician
NPI: 1730192360IndividualAccepts Medicare
Specialties, Licenses & Credentials
Cardiovascular Disease PhysicianPrimary
Internal Medicine — Cardiovascular Disease
Code: 207RC0000X
35067016S(OH)
Education
PERELMAN SCHOOL OF MED AT THE UNIVERSITY OF PENNSYLVANIA
Class of 1987
Research & Publications (20)
Salivary gland homogenates of Lutzomyia longipalpis and its vasodilatory peptide maxadilan cause plasma leakage via PAC1 receptor activation.
PMID 19176972·J Vasc Res·2009
7-preclinical
Proteolytic generation of kinins in tissues infected by Trypanosoma cruzi depends on CXC chemokine secretion by macrophages activated via Toll-like 2 receptors.
PMID 19293401·J Leukoc Biol·2009
7-preclinical
Protease activated receptor signaling is required for African trypanosome traversal of human brain microvascular endothelial cells.
PMID 19621073·PLoS Negl Trop Dis·2009
7-preclinical
Perspectives on the Trypanosoma cruzi-host cell receptor interactions.
PMID 19283409·Parasitol Res·2009
6-review
A recombinant form of chagasin from Trypanosoma cruzi: inhibitory activity on insect cysteine proteinases.
PMID 18318460·Pest Manag Sci·2008
7-preclinical
Angiotensin-converting enzyme limits inflammation elicited by Trypanosoma cruzi cysteine proteases: a peripheral mechanism regulating adaptive immunity via the innate kinin pathway.
PMID 18979626·Biol Chem·2008
6-review
Roles of naturally occurring protease inhibitors in the modulation of host cell signaling and cellular invasion by Trypanosoma cruzi.
PMID 18512348·Subcell Biochem·2008
6-review
The role of conserved residues of chagasin in the inhibition of cysteine peptidases.
PMID 18201565·FEBS Lett·2008
7-preclinical
Bradykinin B2 Receptors of dendritic cells, acting as sensors of kinins proteolytically released by Trypanosoma cruzi, are critical for the development of protective type-1 responses.
PMID 18052532·PLoS Pathog·2007
7-preclinical
The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor family.
PMID 17502099·Structure·2007
4-observational
The propeptide of cruzipain--a potent selective inhibitor of the trypanosomal enzymes cruzipain and brucipain, and of the human enzyme cathepsin F.
PMID 17298440·FEBS J·2007
7-preclinical
Parasite cysteine proteinase interactions with alpha 2-macroglobulin or kininogens: differential pathways modulating inflammation and innate immunity in infection by pathogenic trypanosomatids.
PMID 16446176·Immunobiology·2006
6-review
Cooperative activation of TLR2 and bradykinin B2 receptor is required for induction of type 1 immunity in a mouse model of subcutaneous infection by Trypanosoma cruzi.
PMID 17056563·J Immunol·2006
7-preclinical
Blood-brain barrier traversal by African trypanosomes requires calcium signaling induced by parasite cysteine protease.
PMID 16998589·J Clin Invest·2006
7-preclinical
The substrate specificity of cruzipain 2, a cysteine protease isoform from Trypanosoma cruzi.
PMID 16734782·FEMS Microbiol Lett·2006
7-preclinical
1H, 15N and 13C assignments of the cysteine protease inhibitor chagasin from Trypanosoma cruzi.
PMID 16680406·J Biomol NMR·2006
7-preclinical
Role of chagasin-like inhibitors as endogenous regulators of cysteine proteases in parasitic protozoa.
PMID 16636845·Parasitol Res·2006
6-review
Solution structure and backbone dynamics of the Trypanosoma cruzi cysteine protease inhibitor chagasin.
PMID 16490204·J Mol Biol·2006
7-preclinical
Interplay between parasite cysteine proteases and the host kinin system modulates microvascular leakage and macrophage infection by promastigotes of the Leishmania donovani complex.
PMID 16203170·Microbes Infect·2006
7-preclinical
Chagasin, the endogenous cysteine-protease inhibitor of Trypanosoma cruzi, modulates parasite differentiation and invasion of mammalian cells.
PMID 15713748·J Cell Sci·2005
7-preclinical
Data courtesy of the U.S. National Library of Medicine (NLM). Ltrl is not affiliated with or endorsed by NLM.
Contact & Hours
- Address
- 6801 MAYFIELD ROAD, SUITE 444
MAYFIELD HGTS, OH 44124 - Phone
- (440) 449-8890
Quick Facts
- NPI
- 1730192360
- Entity Type
- Individual
- Gender
- Male
- Medicare
- Accepted
- Specialties
- 1
- Locations
- 1
- Years in Practice
- 39
- Publications
- 20
Are you this provider?
Claim Your Profile