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STEVEN KANNER, MD
MD
Internal Medicine Physician
NPI: 1740270289Individual
Specialties, Licenses & Credentials
Internal Medicine PhysicianPrimary
Internal Medicine
Code: 207R00000X
36451(MA)
Research & Publications (15)
Altering T-cell activation by targeting the multidomain tyrosine kinase Itk.
PMID 12738418·Trends Immunol·2003
6-review
Design, synthesis, and anti-inflammatory properties of orally active 4-(phenylamino)-pyrrolo[2,1-f][1,2,4]triazine p38alpha mitogen-activated protein kinase inhibitors.
PMID 18072718·J Med Chem·2008
7-preclinical
Monoclonal antibodies to six-transmembrane epithelial antigen of the prostate-1 inhibit intercellular communication in vitro and growth of human tumor xenografts in vivo.
PMID 17575147·Cancer Res·2007
7-preclinical
Discovery and SAR of 2-amino-5-(thioaryl)thiazoles as potent and selective Itk inhibitors.
PMID 16682193·Bioorg Med Chem Lett·2006
7-preclinical
Discovery and SAR of 2-amino-5-[(thiomethyl)aryl]thiazoles as potent and selective Itk inhibitors.
PMID 16481166·Bioorg Med Chem Lett·2006
7-preclinical
Imidazoquinoxaline Src-family kinase p56Lck inhibitors: SAR, QSAR, and the discovery of (S)-N-(2-chloro-6-methylphenyl)-2-(3-methyl-1-piperazinyl)imidazo- [1,5-a]pyrido[3,2-e]pyrazin-6-amine (BMS-279700) as a potent and orally active inhibitor with excellent in vivo antiinflammatory activity.
PMID 15317463·J Med Chem·2004
7-preclinical
The discovery of orally active triaminotriazine aniline amides as inhibitors of p38 MAP kinase.
PMID 15566298·J Med Chem·2004
7-preclinical
Selective Itk inhibitors block T-cell activation and murine lung inflammation.
PMID 15323564·Biochemistry·2004
7-preclinical
Discovery and initial SAR of 2-amino-5-carboxamidothiazoles as inhibitors of the Src-family kinase p56(Lck).
PMID 14592495·Bioorg Med Chem Lett·2003
8-other
Correlates of depressive symptoms in adolescents with type 1 diabetes.
PMID 15016153·Pediatr Diabetes·2002
8-other
Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav.
PMID 12186560·Biochemistry·2002
7-preclinical
Nuclear localization of the tyrosine kinase Itk and interaction of its SH3 domain with karyopherin alpha (Rch1alpha).
PMID 11581171·Int Immunol·2001
8-other
Focal adhesion kinase regulates beta1 integrin-dependent T cell migration through an HEF1 effector pathway.
PMID 11465098·Eur J Immunol·2001
8-other
Engagement of the T lymphocyte antigen receptor regulates association of son-of-sevenless homologues with the SH3 domain of phospholipase Cgamma1.
PMID 10940929·Eur J Immunol·2000
8-other
Data courtesy of the U.S. National Library of Medicine (NLM). Ltrl is not affiliated with or endorsed by NLM.
Contact & Hours
- Address
- 210 BEAR HILL RD, SUITE 304
WALTHAM, MA 02451 - Phone
- (781) 684-0600
Quick Facts
- NPI
- 1740270289
- Entity Type
- Individual
- Gender
- Male
- Medicare
- Not confirmed
- Specialties
- 1
- Locations
- 1
- Publications
- 15
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