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KOWSHIK VADDI, D.M.D
D.M.D
Dentist
NPI: 1750583738Individual
Specialties, Licenses & Credentials
DentistPrimary
Dentist
Code: 122300000X
6215-015(WI)0401414337(VA)
Research & Publications (20)
Janus kinase inhibitor INCB20 has antiproliferative and apoptotic effects on human myeloma cells in vitro and in vivo.
PMID 19139110·Mol Cancer Ther·2009
7-preclinical
Potent, selective, orally bioavailable inhibitors of tumor necrosis factor-alpha converting enzyme (TACE): discovery of indole, benzofuran, imidazopyridine and pyrazolopyridine P1' substituents.
PMID 18282708·Bioorg Med Chem Lett·2008
7-preclinical
Potent, exceptionally selective, orally bioavailable inhibitors of TNF-alpha Converting Enzyme (TACE): novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1' substituents.
PMID 18242982·Bioorg Med Chem Lett·2008
7-preclinical
Alpha,Beta-cyclic-beta-benzamido hydroxamic acids: Novel oxaspiro[4.4]nonane templates for the discovery of potent, selective, orally bioavailable inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).
PMID 18234496·Bioorg Med Chem Lett·2008
7-preclinical
Conversion of an MMP-potent scaffold to an MMP-selective HER-2 sheddase inhibitor via scaffold hybridization and subtle P1' permutations.
PMID 18068976·Bioorg Med Chem Lett·2008
8-other
Alpha,beta-cyclic-beta-benzamido hydroxamic acids: novel templates for the design, synthesis, and evaluation of selective inhibitors of TNF-alpha converting enzyme (TACE).
PMID 18061445·Bioorg Med Chem Lett·2008
7-preclinical
Design and identification of selective HER-2 sheddase inhibitors via P1' manipulation and unconventional P2' perturbations to induce a molecular metamorphosis.
PMID 18036818·Bioorg Med Chem Lett·2008
8-other
Discovery of beta-benzamido hydroxamic acids as potent, selective, and orally bioavailable TACE inhibitors.
PMID 18032037·Bioorg Med Chem Lett·2008
7-preclinical
Pharmacokinetics and pharmacodynamics of DPC 333 ((2R)-2-((3R)-3-amino-3{4-[2-methyl-4-quinolinyl) methoxy] phenyl}-2-oxopyrrolidinyl)-N-hydroxy-4-methylpentanamide)), a potent and selective inhibitor of tumor necrosis factor alpha-converting enzyme in rodents, dogs, chimpanzees, and humans.
PMID 17656469·Drug Metab Dispos·2007
3-trial
CC chemokine receptor-3 (CCR3) antagonists: improving the selectivity of DPC168 by reducing central ring lipophilicity.
PMID 17418570·Bioorg Med Chem Lett·2007
7-preclinical
Selective inhibition of ADAM metalloproteases as a novel approach for modulating ErbB pathways in cancer.
PMID 17363546·Clin Cancer Res·2007
7-preclinical
A new 4-(2-methylquinolin-4-ylmethyl)phenyl P1' group for the beta-amino hydroxamic acid derived TACE inhibitors.
PMID 17276676·Bioorg Med Chem Lett·2007
7-preclinical
Discovery of a potent, selective, and orally active human epidermal growth factor receptor-2 sheddase inhibitor for the treatment of cancer.
PMID 17256836·J Med Chem·2007
7-preclinical
Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer.
PMID 16843264·Cancer Cell·2006
7-preclinical
Selective inhibition of ADAM metalloproteases blocks HER-2 extracellular domain (ECD) cleavage and potentiates the anti-tumor effects of trastuzumab.
PMID 16627988·Cancer Biol Ther·2006
7-preclinical
Selective inhibition of eosinophil influx into the lung by small molecule CC chemokine receptor 3 antagonists in mouse models of allergic inflammation.
PMID 16614169·J Pharmacol Exp Ther·2006
4-observational
Synthesis and structure-activity relationship of a novel, achiral series of TNF-alpha converting enzyme inhibitors.
PMID 16516466·Bioorg Med Chem Lett·2006
7-preclinical
CCR2 modulates inflammatory and metabolic effects of high-fat feeding.
PMID 16341265·J Clin Invest·2006
7-preclinical
Discovery and pharmacological characterization of a novel rodent-active CCR2 antagonist, INCB3344.
PMID 16210643·J Immunol·2005
7-preclinical
Synthesis and structure-activity relationship of a novel sulfone series of TNF-alpha converting enzyme inhibitors.
PMID 15357971·Bioorg Med Chem Lett·2004
7-preclinical
Data courtesy of the U.S. National Library of Medicine (NLM). Ltrl is not affiliated with or endorsed by NLM.
Contact & Hours
- Address
- 8353 GREENSBORO DR, SUITE A & B
MC LEAN, VA 22102 - Phone
- (774) 212-3828
Quick Facts
- NPI
- 1750583738
- Entity Type
- Individual
- Gender
- Male
- Medicare
- Not confirmed
- Specialties
- 2
- Locations
- 1
- Publications
- 20
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