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MARGARET BLOUNT, M.D.
M.D.
Family Medicine Physician
NPI: 1811016686Individual
Specialties, Licenses & Credentials
Family Medicine PhysicianPrimary
Family Medicine
Code: 207Q00000X
0101102833(VA)
Research & Publications (20)
Conversion of phosphodiesterase-5 (PDE5) catalytic site to higher affinity by PDE5 inhibitors.
PMID 17690252·J Pharmacol Exp Ther·2007
7-preclinical
A 46-amino acid segment in phosphodiesterase-5 GAF-B domain provides for high vardenafil potency over sildenafil and tadalafil and is involved in phosphodiesterase-5 dimerization.
PMID 16926278·Mol Pharmacol·2006
8-other
Binding of tritiated sildenafil, tadalafil, or vardenafil to the phosphodiesterase-5 catalytic site displays potency, specificity, heterogeneity, and cGMP stimulation.
PMID 15213306·Mol Pharmacol·2004
8-other
Epac regulates UT-A1 to increase urea transport in inner medullary collecting ducts.
PMID 19661162·J Am Soc Nephrol·2009
7-preclinical
Defective peroxisomal proliferators activated receptor gamma activity due to dominant-negative mutation synergizes with hypertension to accelerate cardiac fibrosis in mice.
PMID 19395708·Eur J Heart Fail·2009
4-observational
Phosphorylation of UT-A1 urea transporter at serines 486 and 499 is important for vasopressin-regulated activity and membrane accumulation.
PMID 18495802·Am J Physiol Renal Physiol·2008
7-preclinical
Urea transporters UT-A1 and UT-A3 accumulate in the plasma membrane in response to increased hypertonicity.
PMID 18715940·Am J Physiol Renal Physiol·2008
7-preclinical
Candesartan augments compensatory changes in medullary transport proteins in the diabetic rat kidney.
PMID 18417538·Am J Physiol Renal Physiol·2008
7-preclinical
Phosphorylation increases affinity of the phosphodiesterase-5 catalytic site for tadalafil.
PMID 18199808·J Pharmacol Exp Ther·2008
7-preclinical
In vitro degradation of the inner root sheath in human hair follicles lacking sebaceous glands.
PMID 17970807·Br J Dermatol·2008
8-other
Phosphorylation of phosphodiesterase-5 is promoted by a conformational change induced by sildenafil, vardenafil, or tadalafil.
PMID 17127429·Front Biosci·2007
7-preclinical
Small-scale testing of RFID in a hospital setting: RFID as bed trigger.
PMID 18693863·AMIA Annu Symp Proc·2007
8-other
Forskolin stimulates phosphorylation and membrane accumulation of UT-A3.
PMID 17686955·Am J Physiol Renal Physiol·2007
7-preclinical
PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism.
PMID 17465682·PLoS Genet·2007
4-observational
Vasopressin increases plasma membrane accumulation of urea transporter UT-A1 in rat inner medullary collecting ducts.
PMID 16959825·J Am Soc Nephrol·2006
7-preclinical
Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance.
PMID 17090215·PLoS Biol·2006
7-preclinical
Tamoxifen-induced anorexia is associated with fatty acid synthase inhibition in the ventromedial nucleus of the hypothalamus and accumulation of malonyl-CoA.
PMID 16644689·Diabetes·2006
7-preclinical
High lung PDE5: a strong basis for treating pulmonary hypertension with PDE5 inhibitors.
PMID 16023993·Biochem Biophys Res Commun·2005
7-preclinical
Radiolabeled ligand binding to the catalytic or allosteric sites of PDE5 and PDE11.
PMID 15988068·Methods Mol Biol·2005
7-preclinical
Molecular properties of mammalian proteins that interact with cGMP: protein kinases, cation channels, phosphodiesterases, and multi-drug anion transporters.
PMID 15970481·Front Biosci·2005
6-review
Data courtesy of the U.S. National Library of Medicine (NLM). Ltrl is not affiliated with or endorsed by NLM.
Contact & Hours
- Address
- 106 PARK DRIVE, SUITE A
HOT SPRINGS, VA 24445 - Phone
- (540) 839-8800
Quick Facts
- NPI
- 1811016686
- Entity Type
- Individual
- Gender
- Female
- Medicare
- Not confirmed
- Specialties
- 1
- Locations
- 1
- Publications
- 20
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