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JOSEPH AVRUCH, MD
MD
Endocrinology, Diabetes & Metabolism Physician
NPI: 1851381941Individual
Specialties, Licenses & Credentials
Internal Medicine Physician
Internal Medicine
Code: 207R00000X
34547(MA)
Endocrinology, Diabetes & Metabolism PhysicianPrimary
Internal Medicine — Endocrinology, Diabetes & Metabolism
Code: 207RE0101X
34547(MA)
Research & Publications (20)
Activation of mTORC1 in two steps: Rheb-GTP activation of catalytic function and increased binding of substrates to raptor.
PMID 19143636·Biochem Soc Trans·2009
6-review
The Rheb switch 2 segment is critical for signaling to target of rapamycin complex 1.
PMID 17470430·J Biol Chem·2007
7-preclinical
Insulin and amino-acid regulation of mTOR signaling and kinase activity through the Rheb GTPase.
PMID 17041622·Oncogene·2006
6-review
Recent advances in the regulation of the TOR pathway by insulin and nutrients.
PMID 15586002·Curr Opin Clin Nutr Metab Care·2005
6-review
The p70 S6 kinase integrates nutrient and growth signals to control translational capacity.
PMID 11575164·Prog Mol Subcell Biol·2001
6-review
Ras activation of the Raf kinase: tyrosine kinase recruitment of the MAP kinase cascade.
PMID 11237210·Recent Prog Horm Res·2001
6-review
Nore1 and RASSF1 regulation of cell proliferation and of the MST1/2 kinases.
PMID 16757333·Methods Enzymol·2006
7-preclinical
pTOM, a vector for expressing two proteins in mammalian cells.
PMID 19303393·Anal Biochem·2009
8-other
The TSC-mTOR pathway mediates translational activation of TOP mRNAs by insulin largely in a raptor- or rictor-independent manner.
PMID 19047368·Mol Cell Biol·2009
7-preclinical
The NIMA-family kinase Nek6 phosphorylates the kinesin Eg5 at a novel site necessary for mitotic spindle formation.
PMID 19001501·J Cell Sci·2008
7-preclinical
A Rictor-Myo1c complex participates in dynamic cortical actin events in 3T3-L1 adipocytes.
PMID 18426911·Mol Cell Biol·2008
7-preclinical
The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naïve T cells.
PMID 19073936·Proc Natl Acad Sci U S A·2008
7-preclinical
MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation.
PMID 18328708·Curr Biol·2008
7-preclinical
The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1.
PMID 17517883·J Biol Chem·2007
8-other
Glutamatergic regulation of the p70S6 kinase in primary mouse neurons.
PMID 16183639·J Biol Chem·2005
7-preclinical
Data courtesy of the U.S. National Library of Medicine (NLM). Ltrl is not affiliated with or endorsed by NLM.
Contact & Hours
- Address
- 55 FRUIT STREET, WEL 8
BOSTON, MA 02114 - Phone
- (617) 726-6909
Quick Facts
- NPI
- 1851381941
- Entity Type
- Individual
- Gender
- Male
- Medicare
- Not confirmed
- Specialties
- 2
- Locations
- 1
- Publications
- 20
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