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JOHN HEPLER, M.D.
M.D.
Obstetrics Physician
NPI: 1861498354Individual
Specialties, Licenses & Credentials
Obstetrics PhysicianPrimary
Obstetrics & Gynecology — Obstetrics
Code: 207VX0000X
22925(NC)
Research & Publications (20)
The serine protease plasmin cleaves the amino-terminal domain of the NR2A subunit to relieve zinc inhibition of the N-methyl-D-aspartate receptors.
PMID 19240037·J Biol Chem·2009
7-preclinical
Plasmin potentiates synaptic N-methyl-D-aspartate receptor function in hippocampal neurons through activation of protease-activated receptor-1.
PMID 18474593·J Biol Chem·2008
7-preclinical
The importance of N-terminal polycysteine and polybasic sequences for G14alpha and G16alpha palmitoylation, plasma membrane localization, and signaling function.
PMID 17620339·J Biol Chem·2007
8-other
RGSZ1 interacts with protein kinase C interacting protein PKCI-1 and modulates mu opioid receptor signaling.
PMID 17126529·Cell Signal·2007
7-preclinical
Unique hydrophobic extension of the RGS2 amphipathic helix domain imparts increased plasma membrane binding and function relative to other RGS R4/B subfamily members.
PMID 17848575·J Biol Chem·2007
7-preclinical
Selective interactions between Gi alpha1 and Gi alpha3 and the GoLoco/GPR domain of RGS14 influence its dynamic subcellular localization.
PMID 16870394·Cell Signal·2007
7-preclinical
Cellular mechanisms that determine selective RGS protein regulation of G protein-coupled receptor signaling.
PMID 16647283·Semin Cell Dev Biol·2006
6-review
Cell signalling diversity of the Gqalpha family of heterotrimeric G proteins.
PMID 16182515·Cell Signal·2006
6-review
Differential effects of Gq alpha, G14 alpha, and G15 alpha on vascular smooth muscle cell survival and gene expression profiles.
PMID 15788742·Mol Pharmacol·2005
4-observational
R7BP: a surprising new link between G proteins, RGS proteins, and nuclear signaling in the brain.
PMID 16046666·Sci STKE·2005
6-review
Selective inhibition of alpha1A-adrenergic receptor signaling by RGS2 association with the receptor third intracellular loop.
PMID 15917235·J Biol Chem·2005
8-other
Activation of protease-activated receptor-1 triggers astrogliosis after brain injury.
PMID 15858058·J Neurosci·2005
4-observational
Novel activity of RGS14 on Goalpha and Gialpha nucleotide binding and hydrolysis distinct from its RGS domain and GDI activity.
PMID 15807543·Biochemistry·2005
8-other
RGS2 binds directly and selectively to the M1 muscarinic acetylcholine receptor third intracellular loop to modulate Gq/11alpha signaling.
PMID 14976183·J Biol Chem·2004
7-preclinical
Protease-activated receptor-1 in human brain: localization and functional expression in astrocytes.
PMID 15191806·Exp Neurol·2004
8-other
Methods for measuring RGS protein phosphorylation by G protein-regulated kinases.
PMID 14501052·Methods Mol Biol·2004
6-review
Enhancing compliance at Department of Defense facilities: comparison of three environmental audit tools.
PMID 12690821·J Environ Health·2003
4-observational
Common signaling pathways link activation of murine PAR-1, LPA, and S1P receptors to proliferation of astrocytes.
PMID 14573770·Mol Pharmacol·2003
7-preclinical
Data courtesy of the U.S. National Library of Medicine (NLM). Ltrl is not affiliated with or endorsed by NLM.
Contact & Hours
- Address
- 300 W 27TH ST
LUMBERTON, NC 28358 - Phone
- (910) 671-5000
Quick Facts
- NPI
- 1861498354
- Entity Type
- Individual
- Gender
- Male
- Medicare
- Not confirmed
- Specialties
- 1
- Locations
- 1
- Publications
- 20
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