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EDWARD HAMEL, MD
MD
Pediatrics Physician
NPI: 1871595272Individual
Specialties, Licenses & Credentials
Pediatrics PhysicianPrimary
Pediatrics
Code: 208000000X
MD14850(OR)
Research & Publications (20)
Oxidative stress and cerebrovascular dysfunction in mouse models of Alzheimer's disease.
PMID 17911359·Exp Physiol·2008
6-review
Perivascular nerves and the regulation of cerebrovascular tone.
PMID 16467392·J Appl Physiol (1985)·2006
6-review
New arylthioindoles and related bioisosteres at the sulfur bridging group. 4. Synthesis, tubulin polymerization, cell growth inhibition, and molecular modeling studies.
PMID 19601594·J Med Chem·2009
8-other
Simvastatin improves cerebrovascular function and counters soluble amyloid-beta, inflammation and oxidative stress in aged APP mice.
PMID 19524673·Neurobiol Dis·2009
7-preclinical
The novel Akt inhibitor Palomid 529 (P529) enhances the effect of radiotherapy in prostate cancer.
PMID 19240717·Br J Cancer·2009
8-other
Hybrid alpha-bromoacryloylamido chalcones. Design, synthesis and biological evaluation.
PMID 19250822·Bioorg Med Chem Lett·2009
7-preclinical
2-Arylamino-4-amino-5-aroylthiazoles. "One-pot" synthesis and biological evaluation of a new class of inhibitors of tubulin polymerization.
PMID 19663386·J Med Chem·2009
8-other
Evidence for a distinct ligand binding site on tubulin discovered through inhibition by GDP of paclitaxel-induced tubulin assembly in the absence of exogenous GTP.
PMID 19161972·Arch Biochem Biophys·2009
8-other
Enantioselective synthesis of (+)-chamaecypanone C: a novel microtubule inhibitor.
PMID 19140149·Angew Chem Int Ed Engl·2009
7-preclinical
A diaryl sulfide, sulfoxide, and sulfone bearing structural similarities to combretastatin A-4.
PMID 19135763·Eur J Med Chem·2009
8-other
Demonstration of microtubule-like structures formed with (-)-rhazinilam from purified tubulin outside of cells and a simple tubulin-based assay for evaluation of analog activity.
PMID 19497297·Arch Biochem Biophys·2009
7-preclinical
Intracellular activation and deactivation of tasidotin, an analog of dolastatin 15: correlation with cytotoxicity.
PMID 18927208·Mol Pharmacol·2009
8-other
Pathway-specific variations in neurovascular and neurometabolic coupling in rat primary somatosensory cortex.
PMID 19337274·J Cereb Blood Flow Metab·2009
7-preclinical
Novel microtubule-interacting phenoxy pyridine and phenyl sulfanyl pyridine analogues for cancer therapy.
PMID 18778046·J Med Chem·2008
8-other
Synthesis and biological evaluation of 2-(3',4',5'-trimethoxybenzoyl)-3-N,N-dimethylamino benzo[b]furan derivatives as inhibitors of tubulin polymerization.
PMID 18755591·Bioorg Med Chem·2008
7-preclinical
Complete rescue of cerebrovascular function in aged Alzheimer's disease transgenic mice by antioxidants and pioglitazone, a peroxisome proliferator-activated receptor gamma agonist.
PMID 18784309·J Neurosci·2008
7-preclinical
EF24, a novel curcumin analog, disrupts the microtubule cytoskeleton and inhibits HIF-1.
PMID 18682687·Cell Cycle·2008
8-other
Synthesis and biological evaluation of 2-aroyl-4-phenyl-5-hydroxybenzofurans as a new class of antitubulin agents.
PMID 18991740·Med Chem·2008
7-preclinical
Synthesis and biological evaluation of 2-amino-3-(3',4',5'-trimethoxybenzoyl)-6-substituted-4,5,6,7-tetrahydrothieno[2,3-c]pyridine derivatives as antimitotic agents and inhibitors of tubulin polymerization.
PMID 18725179·Bioorg Med Chem Lett·2008
7-preclinical
Data courtesy of the U.S. National Library of Medicine (NLM). Ltrl is not affiliated with or endorsed by NLM.
Contact & Hours
- Address
- 9300 SE 91ST AVE, SUITE 200
HAPPY VALLEY, OR 97086 - Phone
- (503) 261-1171
Quick Facts
- NPI
- 1871595272
- Entity Type
- Individual
- Gender
- Male
- Medicare
- Not confirmed
- Specialties
- 1
- Locations
- 1
- Publications
- 20
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