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LUKE WHITESELL, MD
MD
Pediatric Hematology & Oncology Physician
NPI: 1881637361Individual
Specialties, Licenses & Credentials
Pediatric Hematology & Oncology PhysicianPrimary
Pediatrics — Pediatric Hematology-Oncology
Code: 2080P0207X
21988(AZ)
Research & Publications (20)
The stress response: implications for the clinical development of hsp90 inhibitors.
PMID 14529386·Curr Cancer Drug Targets·2003
6-review
2,3-Dihydrowithaferin A-3beta-O-sulfate, a new potential prodrug of withaferin A from aeroponically grown Withania somnifera.
PMID 19056281·Bioorg Med Chem·2009
8-other
Inhibiting the transcription factor HSF1 as an anticancer strategy.
PMID 19335068·Expert Opin Ther Targets·2009
6-review
Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease.
PMID 19196973·Proc Natl Acad Sci U S A·2009
7-preclinical
Discovery of quinolinediones exhibiting a heat shock response and angiogenesis inhibition.
PMID 18363347·J Med Chem·2008
8-other
Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis.
PMID 17889646·Cell·2007
7-preclinical
A rhizosphere fungus enhances Arabidopsis thermotolerance through production of an HSP90 inhibitor.
PMID 17631526·Plant Physiol·2007
8-other
A phase I study of 17-allylaminogeldanamycin in relapsed/refractory pediatric patients with solid tumors: a Children's Oncology Group study.
PMID 17363534·Clin Cancer Res·2007
3-trial
Phase I pharmacokinetic and pharmacodynamic study of 17-N-allylamino-17-demethoxygeldanamycin in pediatric patients with recurrent or refractory solid tumors: a pediatric oncology experimental therapeutics investigators consortium study.
PMID 17363533·Clin Cancer Res·2007
3-trial
Search for Hsp90 inhibitors with potential anticancer activity: isolation and SAR studies of radicicol and monocillin I from two plant-associated fungi of the Sonoran desert.
PMID 16499313·J Nat Prod·2006
7-preclinical
A new dihydroxanthenone from a plant-associated strain of the fungus Chaetomium globosum demonstrates anticancer activity.
PMID 16904330·Bioorg Med Chem·2006
8-other
Actin microfilament aggregation induced by withaferin A is mediated by annexin II.
PMID 16408090·Nat Chem Biol·2006
7-preclinical
Hsp90 inhibitors deplete key anti-apoptotic proteins in pediatric solid tumor cells and demonstrate synergistic anticancer activity with cisplatin.
PMID 15455381·Int J Cancer·2005
8-other
An estrogen receptor-alpha/p300 complex activates the BRCA-1 promoter at an AP-1 site that binds Jun/Fos transcription factors: repressive effects of p53 on BRCA-1 transcription.
PMID 16229810·Neoplasia·2005
8-other
The anticancer activity of the fungal metabolite terrecyclic acid A is associated with modulation of multiple cellular stress response pathways.
PMID 16227407·Mol Cancer Ther·2005
7-preclinical
Hsp90 is essential in the filarial nematode Brugia pahangi.
PMID 15862576·Int J Parasitol·2005
7-preclinical
Distinct mouse coronary anatomy and myocardial infarction consequent to ligation.
PMID 15654199·Coron Artery Dis·2005
4-observational
Data courtesy of the U.S. National Library of Medicine (NLM). Ltrl is not affiliated with or endorsed by NLM.
Contact & Hours
- Address
- 1501 N CAMPBELL AVE
TUCSON, AZ 85724 - Phone
- (520) 874-7400
Quick Facts
- NPI
- 1881637361
- Entity Type
- Individual
- Gender
- Male
- Medicare
- Not confirmed
- Specialties
- 1
- Locations
- 1
- Publications
- 20
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