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ERICA SAPP, M.D.
M.D.
Pediatrics Physician
NPI: 1932582780Individual
Specialties, Licenses & Credentials
Pediatrics PhysicianPrimary
Pediatrics
Code: 208000000X
7487(GA)080221(GA)
Research & Publications (16)
Mutant huntingtin and glycogen synthase kinase 3-beta accumulate in neuronal lipid rafts of a presymptomatic knock-in mouse model of Huntington's disease.
PMID 19642201·J Neurosci Res·2010
7-preclinical
Polyglutamine expansion in huntingtin increases its insertion into lipid bilayers.
PMID 19607813·Biochem Biophys Res Commun·2009
8-other
Polyglutamine expansion in huntingtin alters its interaction with phospholipids.
PMID 19566678·J Neurochem·2009
4-observational
A function of huntingtin in guanine nucleotide exchange on Rab11.
PMID 18845944·Neuroreport·2008
7-preclinical
Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits.
PMID 17940007·Proc Natl Acad Sci U S A·2007
7-preclinical
Lysosomal proteases are involved in generation of N-terminal huntingtin fragments.
PMID 16423528·Neurobiol Dis·2006
7-preclinical
Huntingtin associates with acidic phospholipids at the plasma membrane.
PMID 16085648·J Biol Chem·2005
7-preclinical
Huntingtin bodies sequester vesicle-associated proteins by a polyproline-dependent interaction.
PMID 14715959·J Neurosci·2004
7-preclinical
Distribution and ultrastructural localization of torsinA immunoreactivity in the human brain.
PMID 12965225·Brain Res·2003
7-preclinical
Huntingtin is present in the nucleus, interacts with the transcriptional corepressor C-terminal binding protein, and represses transcription.
PMID 11739372·J Biol Chem·2002
7-preclinical
Mice transgenic for exon 1 of the Huntington's disease gene display reduced striatal sensitivity to neurotoxicity induced by dopamine and 6-hydroxydopamine.
PMID 11722604·Eur J Neurosci·2001
7-preclinical
Changes in cortical and striatal neurons predict behavioral and electrophysiological abnormalities in a transgenic murine model of Huntington's disease.
PMID 11717344·J Neurosci·2001
7-preclinical
Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis.
PMID 11675509·Proc Natl Acad Sci U S A·2001
7-preclinical
Early and progressive accumulation of reactive microglia in the Huntington disease brain.
PMID 11273004·J Neuropathol Exp Neurol·2001
8-other
Pro-caspase-8 is predominantly localized in mitochondria and released into cytoplasm upon apoptotic stimulation.
PMID 11102441·J Biol Chem·2001
8-other
Huntingtin expression stimulates endosomal-lysosomal activity, endosome tubulation, and autophagy.
PMID 11007884·J Neurosci·2000
7-preclinical
Data courtesy of the U.S. National Library of Medicine (NLM). Ltrl is not affiliated with or endorsed by NLM.
Contact & Hours
- Address
- 1120 15TH ST
AUGUSTA, GA 30912 - Phone
- (706) 721-8623
Quick Facts
- NPI
- 1932582780
- Entity Type
- Individual
- Gender
- Female
- Medicare
- Not confirmed
- Specialties
- 2
- Locations
- 1
- Publications
- 16
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