11-Deoxycortisol

ChemistryAlso known as: 11-deoxycortisol,lc/ms/msAlso known as: Compound SAlso known as: 11-DOCug/(24.h)

Measures a cortisol precursor in serum or plasma to assess adrenal enzyme function.

Normal Range

0 – 100 ug/(24.h)

ug/(24.h)

Abnormal Levels

Consult your provider

Specimen Type

Blood

Why This Biomarker Matters

Elevated 11-deoxycortisol indicates possible CAH, a serious genetic condition affecting hormone balance. Early diagnosis enables appropriate treatment to prevent serious complications.

Understanding Your Results

Normal Range

0 – 100 ug/(24.h)

Overview

11-deoxycortisol is a precursor hormone in the pathway that produces cortisol, your body's main stress hormone. Elevated urinary 11-deoxycortisol levels typically indicate a deficiency in the enzyme 11β-hydroxylase, which converts this precursor into cortisol. This suggests congenital adrenal hyperplasia (CAH), a genetic disorder affecting steroid hormone production. The test is used to diagnose specific forms of CAH and monitor treatment effectiveness in affected individuals.

Research & Evidence

5 publications

Sort:

Serum steroid profiling by LC-MS/MS in distinguishing adrenocortical carcinoma from other indeterminate adrenal masses.

J Steroid Biochem Mol Biol · 2026

PMID: 41544796Other

Delineating Pediatric Adrenocortical Tumors by GC-MS Urinary Steroid Metabolome Analysis: Observations From the MET Study.

J Clin Endocrinol Metab · 2025

PMID: 41225718Other

[Two cases of Non-classic adrenal hyperplasia: Diagnostic strategies and genetic variant analysis].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi · 2026

PMID: 41918383

Mapping of sex hormones in the testicular vein of healthy men.

J Clin Endocrinol Metab · 2026

PMID: 41921126

A sensitive liquid chromatography-tandem mass spectrometry analytical method of steroid hormones in small blubber samples from four whale species.

Conserv Physiol · 2026

PMID: 41983042

Research data from MEDLINE/PubMed · 5 articles

Technical Information (LOINC Codes)

Standardized laboratory codes for this biomarker

14567-2Primary

11-Deoxycortisol [Moles/volume] in Serum or Plasma

nmol/L

13872-7

11-Deoxycortisol [Mass/time] in 24 hour Urine

ug/(24.h)

42572-8

11-Deoxycortisol [Mass/volume] in Urine

mg/dL

1657-6

11-Deoxycortisol [Mass/volume] in Serum or Plasma

ng/dL;ug/mL

34204-8

11-Deoxycortisol [Moles/volume] in 24 hour Urine

nmol/L

34205-5

11-Deoxycortisol [Moles/volume] in Urine

nmol/L

50071-0

11-Deoxycortisol [Moles/volume] in Amniotic fluid

nmol/L

53338-0

11-Deoxycortisol [Mass/volume] in DBS

ug/dL

53339-8

11-Deoxycortisol [Moles/volume] in DBS

nmol/L

55809-8

11-Deoxycortisol [Mass/volume] in Amniotic fluid

ng/mL

25315-3

11-Deoxycortisol [Moles/time] in 24 hour Urine

nmol/(24.h)

93773-0

11-Deoxycortisol [Moles/volume] in Saliva (oral fluid)

nmol/L

Available Lab Tests

Order tests that measure this biomarker

11 Deoxycortisol Test

$361.24