11-Deoxycortisol

ChemistryAlso known as: 11-deoxycortisol,lc/ms/msAlso known as: Compound SAlso known as: 11-DOCug/(24.h)

Measures a cortisol precursor in serum or plasma to assess adrenal enzyme function.

Normal Range
0 – 100 ug/(24.h)
ug/(24.h)
Abnormal Levels
Consult your provider
Specimen Type
Blood

Why This Biomarker Matters

Elevated 11-deoxycortisol indicates possible CAH, a serious genetic condition affecting hormone balance. Early diagnosis enables appropriate treatment to prevent serious complications.

Understanding Your Results

Normal Range

0 – 100 ug/(24.h)

Overview

11-deoxycortisol is a precursor hormone in the pathway that produces cortisol, your body's main stress hormone. Elevated urinary 11-deoxycortisol levels typically indicate a deficiency in the enzyme 11β-hydroxylase, which converts this precursor into cortisol. This suggests congenital adrenal hyperplasia (CAH), a genetic disorder affecting steroid hormone production. The test is used to diagnose specific forms of CAH and monitor treatment effectiveness in affected individuals.

Research & Evidence

11 publications

Sort:
Serum steroid profiling by LC-MS/MS in distinguishing adrenocortical carcinoma from other indeterminate adrenal masses.
J Steroid Biochem Mol Biol · 2026
PMID: 41544796Other
11-deoxycortisol, other hormones and pituitary function characteristics in the diagnosis of adrenal insufficiency in the overnight oral metyrapone test.
Endocr Connect · 2026
PMID: 42525124
A sensitive liquid chromatography-tandem mass spectrometry analytical method of steroid hormones in small blubber samples from four whale species.
Conserv Physiol · 2026
PMID: 41983042
[Two cases of Non-classic adrenal hyperplasia: Diagnostic strategies and genetic variant analysis].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi · 2026
PMID: 41918383
Mapping of sex hormones in the testicular vein of healthy men.
J Clin Endocrinol Metab · 2026
PMID: 41921126
Protracted osilodrostat-induced pan-adrenal steroidogenic suppression and adrenal size reduction in Cushing disease.
JCEM Case Rep · 2026
PMID: 42494874
Maternal exposure to childhood maltreatment is linked to alterations in the trajectories of steroid hormones during pregnancy.
Psychoneuroendocrinology · 2026
PMID: 42208406
A Novel NR3C1 Frameshift Variant Associated With Familial Glucocorticoid Resistance Syndrome: An Integrated Analysis of Steroid Profiling and Structural Modeling.
Am J Med Genet A · 2026
PMID: 42494305
Steroid hormones in Alzheimer's disease: a molecular analysis of blood and cerebrospinal fluid.
Alzheimers Res Ther · 2026
PMID: 42458616
Evidence for de novo synthesis of corticosteroids in the human ovary.
Hum Reprod · 2026
PMID: 42402373

Research data from MEDLINE/PubMed · 11 articles

Technical Information (LOINC Codes)

Standardized laboratory codes for this biomarker

14567-2Primary
11-Deoxycortisol [Moles/volume] in Serum or Plasma
nmol/L
13872-7
11-Deoxycortisol [Mass/time] in 24 hour Urine
ug/(24.h)
42572-8
11-Deoxycortisol [Mass/volume] in Urine
mg/dL
1657-6
11-Deoxycortisol [Mass/volume] in Serum or Plasma
ng/dL;ug/mL
34204-8
11-Deoxycortisol [Moles/volume] in 24 hour Urine
nmol/L
34205-5
11-Deoxycortisol [Moles/volume] in Urine
nmol/L
50071-0
11-Deoxycortisol [Moles/volume] in Amniotic fluid
nmol/L
53338-0
11-Deoxycortisol [Mass/volume] in DBS
ug/dL
53339-8
11-Deoxycortisol [Moles/volume] in DBS
nmol/L
55809-8
11-Deoxycortisol [Mass/volume] in Amniotic fluid
ng/mL
25315-3
11-Deoxycortisol [Moles/time] in 24 hour Urine
nmol/(24.h)
93773-0
11-Deoxycortisol [Moles/volume] in Saliva (oral fluid)
nmol/L

Available Lab Tests

Order tests that measure this biomarker

11 Deoxycortisol Test

$361.24