3-Hydroxyisobutyrate

ChemistryAlso known as: 3oh-isobutyric acidAlso known as: 3-Hydroxyisobutyric acidN/A

Detects an organic acid in serum or plasma indicating branched-chain amino acid metabolism.

Normal Range

Consult your provider

N/A

Abnormal Levels

Consult your provider

Specimen Type

Blood

Why This Biomarker Matters

Elevated levels may signal inherited metabolic disorders. Early diagnosis allows prompt dietary and medical intervention to prevent developmental and neurological complications.

Overview

3-Hydroxyisobutyrate is an organic acid produced during metabolism of branched-chain amino acids and other nutrients. Elevated urine levels can indicate organic acid disorders, metabolic dysfunction, or nutritional imbalances. This test is used in newborn screening and for evaluating unexplained symptoms like developmental delay, poor feeding, or lethargy. These metabolic conditions require early identification and specialized dietary management to prevent serious health complications and neurological decline.

Technical Information (LOINC Codes)

Standardized laboratory codes for this biomarker

69853-0Primary

3-Hydroxyisobutyrate [Moles/volume] in Serum or Plasma

umol/L

27272-4

3-Hydroxyisobutyrate [Presence] in Urine

69852-2

3-Hydroxyisobutyrate [Moles/volume] in Cerebral spinal fluid

umol/L

Available Lab Tests

Order tests that measure this biomarker

Urinary Organic Acids (94 biomarkers)

$586.08

Results in 7-14 business days