Estrone

ChemistryAlso known as: Estrone 24h Ur-mRateAlso known as: Estrone 24h Ur-sCncAlso known as: Estrone 24h Ur-sRatepg/mL

Measures estrone (a form of estrogen) in saliva to assess your estrogen levels.

Normal Range
12 – 68
pg/mL
Abnormal Levels
< 12 pg/mL
> 68 pg/mL
Specimen Type
Blood

Why This Biomarker Matters

Estrone reflects your hormonal status. Testing helps evaluate menopause symptoms, monitor hormone therapy effectiveness, and assess reproductive or endocrine health.

Optimal Ranges

Clinician-defined 4-point reference thresholds (pg/mL)

Default Range

12
12
68
68
Low
12 pg/mL
Borderline Low
12 pg/mL
Optimal
68 pg/mL
Borderline High
68 pg/mL

male

12
12
68
68
Low
12 pg/mL
Borderline Low
12 pg/mL
Optimal
68 pg/mL
Borderline High
68 pg/mL

female_luteal

15
35
150
170
Low
15 pg/mL
Borderline Low
35 pg/mL
Optimal
150 pg/mL
Borderline High
170 pg/mL

female_follicular

10
30
120
140
Low
10 pg/mL
Borderline Low
30 pg/mL
Optimal
120 pg/mL
Borderline High
140 pg/mL

Overview

Estrone is one of the three main forms of estrogen produced by your body. Salivary estrone measurement offers a non-invasive way to assess estrogen levels and hormonal balance. This test is sometimes used to evaluate menopausal symptoms, monitor hormone replacement therapy, or assess reproductive health. Estrone levels naturally fluctuate throughout the menstrual cycle and decline significantly after menopause. Results help clinicians understand your hormonal status and tailor treatment if needed.

Research & Evidence

19 publications

Sort:
Bone mineral density and bone turnover changes with advanced menstrual recovery: The REFUEL study.
Bone · 2026
PMID: 41707966
Estrobolome: Is there a missing link?
J Steroid Biochem Mol Biol · 2026
PMID: 41707838
Hormonal Modulation of Keratoconus: A Systematic Review and Screening Strategy for At-Risk Populations.
Ophthalmol Sci · 2026
PMID: 41732592
Highly specific ID-UHPLC-MS/MS method for analyzing polar and non-polar steroid hormones.
Anal Bioanal Chem · 2026
PMID: 42056601
Palladium-Catalyzed Late-Stage Alkenylation of Aryl Fluorosulfonates and Phenol-Containing Drugs.
Org Lett · 2026
PMID: 41866723
Effects of limonin and nomilin on lipid metabolic homeostasis in hyperlipidemic mice.
Food Funct · 2026
PMID: 41873636
The association between PFAS exposure, menstrual cycle parameters, and reproductive hormones in adolescent girls.
J Clin Endocrinol Metab · 2026
PMID: 41921573
Catalytic Cycloisomerization-Vinylogous Nazarov Reaction Sequence of Enyne Diesters Derived from 2-Propargyloxyarylaldehydes.
Org Lett · 2026
PMID: 41949326
Premenopausal and postmenopausal obesity and endometrial cancer risk: circulating biomarkers of inflammation, insulin resistance, and sex hormones as mediators.
J Natl Cancer Inst · 2026
PMID: 42015885
LC-MS/MS-based simultaneous high-sensitivity quantification of clinically relevant high-potency androgens and estrogens in plasma and serum.
J Chromatogr B Analyt Technol Biomed Life Sci · 2026
PMID: 41762488

Research data from MEDLINE/PubMed · 19 articles

Technical Information (LOINC Codes)

Standardized laboratory codes for this biomarker

2258-2Primary
Estrone (E1) [Mass/volume] in Serum or Plasma
pg/mL
27998-4
Estrone (E1) [Mass/volume] in Saliva (oral fluid)
pg/mL
22663-9
Estrone (E1) [Moles/volume] in Serum or Plasma
pmol/L
25403-7
Estrone (E1) [Moles/volume] in Urine
pmol/L
31177-9
Estrone (E1) [Mass/volume] in Amniotic fluid
pg/mL
34297-2
Estrone (E1) [Moles/volume] in 24 hour Urine
pmol/L
34298-0
Estrone (E1) [Moles/time] in 24 hour Urine
pmol/(24.h)
2257-4
Estrone (E1) [Mass/volume] in Semen
ng/dL
6776-9
Estrone (E1) [Mass/time] in 24 hour Urine
ng/(24.h)
2259-0
Estrone (E1) [Mass/volume] in Urine
ng/dL

Available Lab Tests

Order tests that measure this biomarker

Estrone (LC/MS/MS)

$56.38
Results in 3-5 business days