Protein

ChemistryAlso known as: Total proteing/dL

Measures protein concentration in pericardial fluid surrounding the heart.

Normal Range
2.5 – 4.2 g/dL
g/dL
Abnormal Levels
< 6.1 g/dL
> 8.1 g/dL
Specimen Type
Blood

Why This Biomarker Matters

Abnormal pericardial protein indicates heart inflammation, infection, or malignancy. This test helps diagnose serious heart conditions and guides treatment decisions.

Understanding Your Results

Normal Range

2.5 – 4.2 g/dL

Optimal Ranges

Clinician-defined 4-point reference thresholds (g/dL)

Default Range

6.1
6.4
7.8
8.1
Low
6.1 g/dL
Borderline Low
6.4 g/dL
Optimal
7.8 g/dL
Borderline High
8.1 g/dL

Overview

Protein in pericardial fluid (fluid surrounding the heart) reflects inflammation, infection, or leakage from blood vessels. This test helps diagnose conditions like pericarditis (heart inflammation), infection, or malignancy affecting the pericardium. Elevated protein in pericardial fluid typically indicates an exudative process requiring further investigation. Results guide diagnosis and determine if drainage or specific treatment like antibiotics is needed.

Related Health Conditions

Conditions where Protein is commonly tested

Proteinuria

Related Health Goals

Improve Kidney Health

Clinical Trials

61
Total Trials
12
Recruiting
10
With Results

Recent Trials

Family Investigation of Nephropathy and Diabetes (F.I.N.D.)

NCT00342927Recruiting100,000 enrolled

Study of Ravulizumab in Immunoglobulin A Nephropathy (IgAN)

NCT06291376Phase 3Recruiting510 enrolled

Empagliflozin Treatment in Kidney Transplant Recipients

NCT06013865Phase 4Recruiting264 enrolled

Nefecon and Ambrisentan in IgA Nephropathy

NCT07030894Phase 4Recruiting129 enrolled

A Study to Learn More About How Safe the Study Treatment Finerenone is in Long-term Use When Taken With an ACE Inhibitor or Angiotensin Receptor Blocker Over 18 Months of Use in Children and Young Adults From 1 to 18 Years of Age With Chronic Kidney Disease and Proteinuria

NCT05457283Phase 3Recruiting100 enrolled
View all 61 trials on ClinicalTrials.gov

Research & Evidence

23 publications

Sort:
Effect of empagliflozin on urinary albumin excretion and hypoxic biomarkers in early diabetic kidney disease: A randomised double-blind, placebo-controlled trial.
Diabetes Obes Metab · 2026
PMID: 41582689Other
Long-term outcomes of initial tonsillectomy and steroid pulse therapy in children with IgA nephropathy and heavy proteinuria: a single-center retrospective study.
Clin Exp Nephrol · 2026
PMID: 41580560Other
Immunosuppressive strategies for renal&#xa0;function preservation in IgA nephropathy with partial crescent formation: A retrospective cohort study.
Clin Nephrol · 2026
PMID: 41553148Other
Effects of Empagliflozin on Urine Biomarkers in EMPA-KIDNEY.
Am J Kidney Dis · 2025
PMID: 41177216Other
Association between Complete Proteinuria Remission and Kidney Function in the Phase 3 PROTECT Trial of Sparsentan in IgA Nephropathy.
Clin J Am Soc Nephrol · 2025
PMID: 41428405Other
[Effects of initial periodontal therapy on renal prognosis in patients with chronic kidney disease and periodontitis].
Zhonghua Kou Qiang Yi Xue Za Zhi · 2026
PMID: 41913608
High-normal levels of B-type natriuretic peptide are associated with chronic kidney disease progression independent of albuminuria in individuals with diabetes: an observational cohort study.
Diabetes Res Clin Pract · 2026
PMID: 41747771
Loss of NGAL protects against albumin-induced kidney inflammation and fibrosis.
Ren Fail · 2026
PMID: 41877356
Impact of Glucagon-Like Peptide-1 Receptor Agonists on Proteinuria in Kidney Transplant Recipients.
Pharmacotherapy · 2026
PMID: 41800749
Comparison of SGLT2 Inhibitors for New-Onset Proteinuria Risk in Patients With Type 2 Diabetes and Preserved Kidney Function.
Diabetes Obes Metab · 2026
PMID: 41804189

Research data from MEDLINE/PubMed · 23 articles

Technical Information (LOINC Codes)

Standardized laboratory codes for this biomarker

2885-2Primary
Protein [Mass/volume] in Serum or Plasma
g/dL
2889-4
Protein [Mass/time] in 24 hour Urine
g/(24.h)
21482-5
Protein [Mass/volume] in 24 hour Urine
g/dL
2881-1
Protein [Mass/volume] in Body fluid
g/dL
2880-3
Protein [Mass/volume] in Cerebral spinal fluid
mg/dL
2888-6
Protein [Mass/volume] in Urine
g/dL
35663-4
Protein [Mass/volume] in Urine collected for unspecified duration
mg/dL
33407-8
Protein [Mass/volume] in Pericardial fluid
g/dL
32551-4
Protein [Mass] in Urine collected for unspecified duration
g
47739-8
Protein [Mass/volume] in Stool
g/L
50749-1
Protein [Interpretation] in Urine
58992-9
Protein [Mass/time] in 18 hour Urine
mg/(18.h)
26801-1
Protein [Mass/time] in 12 hour Urine
mg/(12.h)
2883-7
Protein [Mass/volume] in Peritoneal fluid
g/L
18373-1
Protein [Mass/time] in 6 hour Urine
mg/(6.h)
32209-9
Protein [Presence] in 24 hour Urine by Test strip
12842-1
Protein [Mass/volume] in 12 hour Urine
g/dL
21028-6
Protein [Interpretation] in 24 hour Urine
2886-0
Protein [Mass/volume] in Synovial fluid
g/L
2882-9
Protein [Mass/volume] in Pleural fluid
g/L
53525-2
Protein [Presence] in Urine by SSA method
27298-9
Protein [Units/volume] in Urine
[arb'U]/mL
57735-3
Protein [Presence] in Urine by Automated test strip
32337-8
Protein [Mass/volume] in Specimen
g/L
20454-5
Protein [Presence] in Urine by Test strip
5804-0
Protein [Mass/volume] in Urine by Test strip
mg/dL
50561-0
Protein [Mass/volume] in Urine by Automated test strip
mg/dL
2887-8
Protein [Presence] in Urine
80832-9
Protein [Mass/volume] in Lower respiratory specimen
mg/mL
12843-9
Protein [Mass/volume] in Peritoneal dialysis fluid
g/L
14387-5
Protein [Mass/volume] in Gastric fluid
g/dL
2878-7
Protein [Mass/volume] in Amniotic fluid
g/dL
2879-5
Protein [Presence] in Cerebral spinal fluid
2884-5
Protein [Mass/volume] in Semen
g/dL
29748-1
Protein [Mass/mass] in Tissue
mg/g
53121-0
Protein [Mass/time] in 1 hour Urine
mg/h
5920-4
Protein [Mass/volume] in Dialysis fluid
g/L
77359-8
Protein [Mass/volume] in Saliva (oral fluid)
g/L
107377-4
Protein [Mass/volume] in Blood
g/L

Available Lab Tests

Order tests that measure this biomarker

Advanced Liver Health Comprehensive

$1044.34

Urinalysis Complete

$18.76
Results in Same day to 1 business day

Urinalysis Complete Test with Reflex to Culture

$24.64

Find Specialists

Doctors who commonly order this test

Internal Medicine
Nephrology