Overview
Common variable immunodeficiency is a disorder.
Auto-generated from clinical reference data. Not a substitute for medical advice.
Signs & Symptoms
Based on Human Phenotype Ontology (HPO) disease-phenotype annotations.
B cell lymphopenia
Always present (100%)HP:0010976
Decreased class-switched memory B cell proportion
Always present (100%)HP:0030388
Decreased serum IgG
Always present (100%)HP:0004315
Low levels of immunoglobulin A
Always present (100%)HP:0002720
Recurrent bacterial infections
Always present (100%)HP:0002718
Decreased circulating total IgM
Frequent (30-79%)HP:0002850
Neutropenia in presence of anti-neutropil antibodies
Occasional (5-29%)HP:0001904
Abnormal number of T cells
Excluded (<1%)HP:0011839
Bronchiectasis
HP:0002110
Bronchitis, recurrent
HP:0002837
Conjunctivitis, recurrent
HP:0000509
Diarrhea
HP:0002014
Enlarged liver
HP:0002240
Immune deficiency
HP:0002721
Impaired T cell function
HP:0011840
Large spleen
Excluded (<1%)HP:0001744
Lymph node hyperplasia
HP:0002716
Multiple pulmonary infections
HP:0006532
Pneumonia
HP:0002090
Recurrent middle ear infection
HP:0000403
Recurrent sinus disease
HP:0011108
Related Conditions
Common variable agammaglobulinemia(child)
Common variable immunodeficiency with predominant abnormalities of B-cell numbers and functions(child)
Common variable immunodeficiency with predominant immunoregulatory T-cell disorders(child)
Common variable immunodeficiency with autoantibodies to B- or T-cells(child)
Autosomal recessive CVID (common variable immunodeficiency) due to CD81 deficiency(child)
CVID (common variable immunodeficiency) due to TACI deficiency(child)
X-linked common variable immunodeficiency due to SH3KBP1 deficiency(child)
Autosomal recessive common variable immunodeficiency due to CD20 mutation(child)
Autosomal recessive common variable immunodeficiency due to CR2 mutation(child)
Autosomal recessive combined variable immunodeficiency due to B cell-activating factor receptor mutation(child)
Autosomal dominant combined variable immunodeficiency due to TWEAK deficiency(child)
Autosomal dominant combined variable immunodeficiency due to nuclear factor kappa B subunit 1 mutation(child)
Autosomal dominant combined variable immunodeficiency due to IRF2BP2 deficiency(child)
Autosomal recessive combined variable immunodeficiency due to ARHGEF1 mutation(child)
Autosomal dominant combined variable immunodeficiency due to SEC61A1 deficiency(child)
Autosomal recessive CVID (combined variable immunodeficiency) due to PIK3CG deficiency(child)
Autosomal recessive common variable immunodeficiency due to POU2AF1 mutation(child)
Autosomal recessive common variable immunodeficiency due to Rac family small GTPase 2 deficiency(child)
Primary immune deficiency disorder(parent)
Disorder of immune structure(parent)
Quick Facts
- SNOMED CT
- 191010004
- UMLS CUI
- C0009447
- Fully Specified Name
- Common variable immunodeficiency (disorder)
- Specialists
- 0
- Diagnostic Biomarkers
- 0
- HPO Phenotypes
- 21
Medical Disclaimer
This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.
Clinical content is derived from the SNOMED CT clinical ontology and curated medical knowledge graphs.