Overview
By MedlinePlus, National Library of Medicine
Centers for Disease Control and Prevention Courtesy of the National Library of Medicine. Source: MedlinePlus.gov, National Library of Medicine. Not a substitute for medical advice.
Research Evidence
Peer-reviewed studies linked via MeSH term "Infection, Zika Virus" from the MEDLINE/PubMed database.
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Zika Virus-Related Birth Defects and Neurological Complications: A Systematic Review and Meta-Analysis.
[object Object], [object Object], [object Object] et al. · Rev Med Virol · 2025
PMID: 40037985Meta-Analysis
Envelope Protein in Differential Serodiagnosis of Dengue, Zika and Chikungunya Viruses: A Systematic Review.
[object Object], [object Object], [object Object] et al. · Curr Top Med Chem · 2025
PMID: 39428933Meta-Analysis
Neuroteratogenic mechanisms of Zika virus (ZIKV) infection: Insights into fetal brain development disruption and congenital Zika syndrome: A systematic review.
[object Object], [object Object], [object Object] et al. · Mol Aspects Med · 2025
PMID: 41145040Meta-Analysis
The association between maternal immune activation and brain structure and function in human offspring: a systematic review.
[object Object], [object Object], [object Object] et al. · Mol Psychiatry · 2025
Zika virus infection and acute transverse myelitis: a comprehensive systematic review.
[object Object], [object Object] · Rev Inst Med Trop Sao Paulo · 2024
Prevalence of dengue, Zika, and chikungunya virus infections among mosquitoes in Asia: A systematic review and meta-analysis.
[object Object], [object Object], [object Object] et al. · Int J Infect Dis · 2024
PMID: 39216785Meta-Analysis
Clinical manifestations of dengue, Zika and chikungunya in the Pacific Islands: A systematic review and meta-analysis.
[object Object], [object Object] · Rev Med Virol · 2024
PMID: 38340071Meta-Analysis
Integrative role of small non-coding RNAs in viral immune response: a systematic review.
[object Object], [object Object], [object Object] · Mol Biol Rep · 2024
PMID: 38227137Meta-Analysis
Global seroprevalence of Zika virus in asymptomatic individuals: A systematic review.
[object Object], [object Object], [object Object] et al. · PLoS Negl Trop Dis · 2024
Prenatal and Postnatal Ocular Abnormalities Following Congenital Zika Virus Infections: A Systematic Review.
[object Object], [object Object], [object Object] et al. · Ocul Immunol Inflamm · 2024
PMID: 38350011Meta-Analysis
Search all PubMed articles for Zika virus disease
Research data from MEDLINE/PubMed
Signs & Symptoms
Based on Human Phenotype Ontology (HPO) disease-phenotype annotations.
Maculopapular exanthema
Very frequent (80-99%)HP:0040186
Skin rash
Very frequent (80-99%)HP:0000988
Abnormal cerebrospinal fluid morphology
Frequent (30-79%)HP:0002921
Arthritic pain
Frequent (30-79%)HP:0002829
Conjunctivitis, recurrent
Frequent (30-79%)HP:0000509
Headache
Frequent (30-79%)HP:0002315
Increased IgM levels
Frequent (30-79%)HP:0003496
Joint inflammation
Frequent (30-79%)HP:0001369
Muscle pain
Frequent (30-79%)HP:0003326
Pyrexia
Frequent (30-79%)HP:0001945
Skin itching
Frequent (30-79%)HP:0000989
Ankle swelling
Occasional (5-29%)HP:0001785
Transient hearing impairment
Occasional (5-29%)HP:0012779
Vomiting
Occasional (5-29%)HP:0002013
Water retention
Occasional (5-29%)HP:0000969
Wrist swelling
Occasional (5-29%)HP:0001225
Abnormal optic disc morphology
Very rare (1-4%)HP:0012795
Acute demyelinating polyneuropathy
Very rare (1-4%)HP:0007131
Bleeding below the skin
Very rare (1-4%)HP:0001933
Brain inflammation
Very rare (1-4%)HP:0002383
Chorioretinal atrophy
Very rare (1-4%)HP:0000533
Congenital intracerebral calcification
Very rare (1-4%)HP:0006906
Decreased size of cranium
Very rare (1-4%)HP:0000252
Hypoplastic optic discs
Very rare (1-4%)HP:0007766
Inflammation of spinal cord
Very rare (1-4%)HP:0012486
Intrauterine growth retardation, IUGR
Very rare (1-4%)HP:0001511
Iris coloboma
Very rare (1-4%)HP:0000612
Loss of foveal reflex
Very rare (1-4%)HP:0030825
Macular atrophy
Very rare (1-4%)HP:0007401
Meningitis
Very rare (1-4%)HP:0001287
Quick Facts
- SNOMED CT
- 3928002
- UMLS CUI
- C0276289
- Fully Specified Name
- Zika virus disease (disorder)
- Specialists
- 0
- Diagnostic Biomarkers
- 0
- HPO Phenotypes
- 30
Medical Disclaimer
This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.
Clinical content is derived from the SNOMED CT clinical ontology and curated medical knowledge graphs.