Substance / Medication

125-I

Overview

Clinical overview including description, indications, and evidence base is pending physician authorship or FDA SPL integration. Graph-derived relationship data is available below.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Disorder of thyroid gland

Staphylococcal infectious disease

Postoperative wound infection

Ulcer of lower limb

Burn

Surgical site infection

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Research Evidence

Published studies and systematic reviews

Sort:

Clinical and physical determinants for toxicity of 125-I seed prostate brachytherapy.

Albertsen Peter C · J Urol · 2005

PMID: 16217368Observational

[The optimal mating time in the bitch based on the progesterone concentration in peripheral blood. A comparison of reliability between three ELISA test kits and a 125-iodine radioimmunoassay].

van Klaveren N J, Kooistra H S, Dieleman S J et al. · Tijdschr Diergeneeskd · 2001

PMID: 11723806Observational

Review of radiosurgery of pineal parenchymal tumors. Long survival following 125-iodine brachytherapy of pineoblastomas in 2 cases.

Julow J, Viola A, Major T · Minim Invasive Neurosurg · 2006

PMID: 17163340Case Report

[125-I brachytherapy of pineal parenchymal tumours in two patients and review of the literature].

Julow Jeno, Viola Arpád, Major Tibor et al. · Ideggyogy Sz · 2005

PMID: 16175667Case Report

[3D printing non-coplanar template-assisted 125-iodine seed implantation for thorax movement tumor: individual template design method].

Sun H T, Jiang Y L, Ji Z et al. · Zhonghua Yi Xue Za Zhi · 2019

PMID: 31874493Other

Application of the transosseous approach for computed tomography-guided radioactive 125-iodine seed implantation for the treatment of thoracic and abdominal lymph node metastases.

Chen Jian, Chen Jin, Lin Xiu-Hua et al. · J Cancer Res Ther · 2019

PMID: 31939445Other

[3D printed template-assisted and computed tomography image-guided 125-iodine seed implantation for supraclavicular metastatic tumor: a dosimetric study].

Beijing Da Xue Xue Bao Yi Xue Ban · 2017

PMID: 28628155Other

[SP600125-induced polyploidization of megakaryocytic leukemia cell lines by ribosomal protein S6 kinase 1 depends on the degree of cell differentiation].

Wang Lili, Yang Jingang, Li Changling et al. · Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi · 2016

PMID: 27667458Other

[Protein kinase A inhibitor H-89 blocks polyploidization of SP600125-induced CMK cells by regulating phosphorylation of ribosomal protein S6 kinase 1].

Zhao Song, Yang Jingang, Li Changling et al. · Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi · 2016

PMID: 27667455Other

Acute immune stress improves cell resistance to chemical poison damage in SP600125-induced polyploidy of fish cells in vitro.

Mo Yanxiu, Fan Yunpeng, Fu Wen et al. · Fish Shellfish Immunol · 2019

PMID: 30393156Preclinical

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type: Substance / Medication
Fully Specified Name: Iodine-125 (substance)
SNOMED CT: 68630002
UMLS CUI: C0796396

Clinical Data

This intervention maps to 6 entities in the Healos knowledge graph.

Conditions

Biomarkers

Specialists

Symptoms

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.